Article (Scientific journals)
CFD-based Compartment model for description of mixing in bioreactors
Delafosse, Angélique; Calvo, Sébastien; Collignon, Marie-Laure et al.
2014In Chemical Engineering Science, 106, p. 76-85
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Keywords :
Bioreactor; Stirred tank; Mixing; CFD; Compartment model; Mixing comparison
Abstract :
[en] In most bioprocesses, it is fundamental to accurately predict the hydrodynamics behavior of bioreactors of different size and its interaction with the biological reaction. Computational Fluid Dynamics can provide detailed modeling about hydrodynamics and mixing. However, it is computationally intensive, especially when reactions are taken into account. Another way to predict hydrodynamics is the use of “Compartment” or “Network-of-zones” model which are much less demanding in computation time than CFD. However, compartments and fluxes between them are often defined by considering global quantities not representative of the flow complexity. To overcome the limitations of these two methods, a solution is to combine compartment modeling and CFD simulations. The aim of this study is to propose a compartment model where the flow rates between two adjacent compartments are easily computed from the velocity fields obtained by CFD. The mixing evolution predicted by the CFD-based compartment model have been then compared with mixing experiment results. Unlike a CFD mixing simulation and a classical compartment model, the CFD-based compartment model proposed in this work reproduces with a good accuracy the spatial distribution of concentrations during the mixing process and this, without any adjustable parameters.
Research center :
Laboratory of Chemical Engineering
Disciplines :
Chemical engineering
Author, co-author :
Delafosse, Angélique ;  Université de Liège - ULiège > Département de chimie appliquée > Génie chimique - Génie catalytique
Calvo, Sébastien ;  Université de Liège - ULiège > Département de chimie appliquée > Génie de la réaction et des réacteurs chimiques
Collignon, Marie-Laure ;  Université de Liège - ULiège > Département de chimie appliquée > Département de chimie appliquée
Delvigne, Frank  ;  Université de Liège - ULiège > Chimie et bio-industries > Bio-industries
Crine, Michel ;  Université de Liège - ULiège > Département de chimie appliquée > Génie chimique - Opérations physiques unitaires
Thonart, Philippe ;  Université de Liège - ULiège > Département des sciences de la vie > Biochimie et microbiologie industrielles
Toye, Dominique  ;  Université de Liège - ULiège > Département de chimie appliquée > Génie de la réaction et des réacteurs chimiques
Language :
English
Title :
CFD-based Compartment model for description of mixing in bioreactors
Publication date :
17 March 2014
Journal title :
Chemical Engineering Science
ISSN :
0009-2509
eISSN :
1873-4405
Publisher :
Pergamon Press - An Imprint of Elsevier Science, Oxford, United Kingdom
Volume :
106
Pages :
76-85
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 20 November 2013

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