Reference : Molecular adaptations to cold in psychrophilic enzymes
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Molecular adaptations to cold in psychrophilic enzymes
Feller, Georges mailto [Université de Liège - ULg > Département des sciences de la vie > Labo de biochimie >]
Cellular and Molecular Life Sciences : CMLS
Yes (verified by ORBi)
[en] psychrophile ; extremophile ; enzyme kinetics ; crystal structure ; folding ; mutagenesis ; biophysics
[en] Psychrophiles or cold-loving organisms successfully colonize cold environments of the Earth's biosphere. To cope with the reduction of chemical reaction rates induced by low temperatures, these organisms synthesize enzymes characterized by a high catalytic activity at low temperatures associated, however, with low thermal stability. Thanks to recent advances provided by Xray crystallography, protein engineering and biophysical studies, we are beginning to understand the molecular adaptations responsible for these properties which appear to be relatively diverse. The emerging picture suggests that psychrophilic enzymes utilize an improved flexibility of the structures involved in the catalytic cycle, whereas other protein regions if not implicated in catalysis may or may not be subjected to genetic drift.

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