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Poster (Scientific congresses and symposiums)
INFLUENCE OF THE NATURE OF SUGAR RESIDUES ON THE INTERACTIONS OF SYMETRIC SUGAR- BASED BOLAFORMS WITH MODEL MEMBRANES
Nasir, Mehmet Nail; Crowet, Jean-Marc; Lins, Laurence et al.
2013GEM-GERLI Conference
 

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Keywords :
glycolipid; surfactant; drug delivery; Elicitor; bolaform; rhamnose; xylose
Abstract :
[en] Glycolipid surfactants constitute a class of natural compound having interest in biological field such as antifungal, antiviral and plant-elicitor and for pharmaceutical formulation as well as for food and cosmetic field. Their action may be modulated through their interactions with plasma membranes of target cells and more particularly by their interactions with membrane lipid molecules. Among glycolipid surfactants, bolaforms constitute an important class; they are composed of two hydrophilic heads connected by a hydrophobic carbon segment.Their interest lies mainly in the development of the efficient and low cost lipid-based drug delivery systems. In this context, our work was focused on two sugar-based bolaforms. They are composed by two identical hydrophilic head constituted by xylose ( BolaX) or rhamnose ( BolaR), connected by an ether link to a hydrocarbon segment with an insaturation. The interactions of  BolaX and BolaR with model phopsholipid and phospholipid/sterol model membranes (Langmuir monolayers at the air-water interface and multilamellar vesicles) were investigated with biophysical and in silico approaches. Our results indicate that both bolaforms interact with model membranes at the level of hydrocarbon chain and, at the phosphate and the carbonyl group of phospholipids. The presence of sterol in the system has an influence on insertion of bolaforms and change slightly the nature of the interactions. The insertion of BolaR within a phospholipid bilayer was deeper than that of  BolaX and its interactions with phospholipids were energetically more favorable, suggesting an important role of the nature of sugar residue.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Nasir, Mehmet Nail ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie générale et organique
Crowet, Jean-Marc ;  Université de Liège - ULiège > Chimie et bio-industries > Biophysique moléc. numér.
Lins, Laurence  ;  Université de Liège - ULiège > Chimie et bio-industries > Biophysique moléc. numér.
Ongena, Marc ;  Université de Liège - ULiège > Chimie et bio-industries > Bio-industries
Fauconnier, Marie-Laure  ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie générale et organique
Gatard, Sylvain
Bouquillon, Sandrine
Deleu, Magali  ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Language :
English
Title :
INFLUENCE OF THE NATURE OF SUGAR RESIDUES ON THE INTERACTIONS OF SYMETRIC SUGAR- BASED BOLAFORMS WITH MODEL MEMBRANES
Publication date :
November 2013
Event name :
GEM-GERLI Conference
Event place :
France
Event date :
du 10 au 15 Novembre
Audience :
International
Name of the research project :
ARC FIELD
Funders :
FWB - Fédération Wallonie-Bruxelles [BE]
Available on ORBi :
since 08 November 2013

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