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IS ULTRA-SHORT COLD ISCHEMIA THE KEY TO ISCHEMIC CHOLANGIOPATHY AVOIDANCE IN DCD- LT?
DETRY, Olivier; DE ROOVER, Arnaud; Cheham, Samir et al.
201316th Congress of the European Society for Organ Transplantation
 

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Keywords :
NHBD; results
Abstract :
[en] Introduction: Donation after circulatory death (DCD) donors have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of ischemic cholangiopathy leading to graft loss. The authors retrospectively reviewed a single centre experience with DCD-LT in a 9-year period. Patients and Methods: 70 DCD-LT were performed from 2003 to November 2012. All DCD procedures were performed in operative rooms. Median donor age was 59 years. Most grafts were flushed with HTK solution. Allocation was centre-based. Median total DCD warm ischemia was 19.5 min. Mean follow-up was 36 months. No patient was lost to follow-up. Results: Median MELD score at LT was 15. Median cold ischemia was 235 min. Median peak AST was 1,162 U/L. Median peak bilirubin was 31.2 mg/dL. Patient and graft survivals were 92.8% and 91.3% at one year and 79% and 77.7% at 3 years, respectively. One graft was lost due to hepatic artery thrombosis. No PNF or graft loss due to ischemic cholangiopathy was observed in this series. Causes of death were malignancies in 8 cases. Discussion: In this series, DCD LT appears to provide results equal to classical LT. Short cold ischemia and recipient selection with low MELD score may be the keys to good results in DCD LT, in terms of graft survival and avoidance of ischemic cholangiopathy.
Disciplines :
Gastroenterology & hepatology
Surgery
Anesthesia & intensive care
Author, co-author :
DETRY, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
DE ROOVER, Arnaud ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Cheham, Samir
Le Dinh, Hieu
COIMBRA MARQUES, Carla ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
DECKER, Emmanuel ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
KOHNEN, Laurent ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
DELBOUILLE, Marie-Hélène ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
JORIS, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
LAUWICK, Séverine ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
KABA, Abdourahmane ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
DELWAIDE, Jean ;  Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
MEURISSE, Michel ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
HONORE, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
More authors (4 more) Less
Language :
English
Title :
IS ULTRA-SHORT COLD ISCHEMIA THE KEY TO ISCHEMIC CHOLANGIOPATHY AVOIDANCE IN DCD- LT?
Publication date :
December 2013
Event name :
16th Congress of the European Society for Organ Transplantation
Event organizer :
European Society for Organ Transplantation (ESOT) et European Liver Intestine Transplant Association (ELITA)
Event place :
Vienna, Austria
Event date :
du 8 au 11 septembre 2013
Audience :
International
References of the abstract :
Transplant International(2013), 26(S2), 53-BO98.
Available on ORBi :
since 06 November 2013

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