[en] The purpose of the present study is to find the conditions allowing to reach the highest 24 h-yield(24 h- ) for the synthesis of mannosyl myristate catalyzed by the immobilized lipase B from Candida antarctica (Novozym®435) in the ionic liquid (IL) [Bmpyrr][TFO] (1-butyl-1-methylpyrrolidinium tri-fluoromethanesulfonate). A full factorial design (FFD) was used in order to study the influence of three variables (temperature, mannose/vinyl myristate ratio and total substrate quantity) on the 24 h- . This design led to a model based on a second order polynomial response function. The resulting predicted con-tour plots have shown that the highest 24 h- should be obtained with high temperatures, low sugar/vinylester molar ratio and intermediate total substrate quantities (mmol). The model has been successfully verified and experimentally confirmed at the optimal conditions of 80◦C, substrate molar ratio of 1/10and total substrate quantity of 0.26 mmol leading to the highest predicted 24 h- of 72.2%.
Disciplines :
Biotechnology
Author, co-author :
Galonde, Nadine ; Université de Liège - ULiège > Chimie et bio-industries > Chimie générale et organique
Brostaux, Yves ; Université de Liège - ULiège > Sciences agronomiques > Statistique, Inform. et Mathém. appliquée à la bioingénierie
Richard, Gaetan ; Université de Liège - ULiège > Chimie et bio-industries > Analyse, qual. et risques - Labo. de Chimie analytique
Nott, Katherine ; Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Jérôme, Christine ; Université de Liège - ULiège > Département de chimie (sciences) > Centre d'études et de rech. sur les macromolécules (CERM)
Fauconnier, Marie-Laure ; Université de Liège - ULiège > Chimie et bio-industries > Chimie générale et organique
Language :
English
Title :
Use of response surface methodology for the optimization of the lipase-catalyzed synthesis of mannosyl myristate in pure ionic liquid
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