Poster (Scientific congresses and symposiums)
Inhibition of Tax transformation activity using a small molecule targetting Tax/PDZ domain interactions.
Blibek, Karim; Fujii, Naoaki; Legros, Sebastien et al.
201316th International Conference on Human Retrovirology: HTLV and Related Viruses HTLV
 

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Keywords :
HTLV-1; Tax; PDZ; Transformation
Abstract :
[en] Primate T-lymphotropic virus species comprise four members (HTLV-1 to -4) that have been discovered in human. Only the HTLV-1 infection leads to adult T-cell leukemia/lymphoma (ATLL) and tropical spastic paraparesis (TSP), an immune degenerative neurologic syndrome. All the four viruses share a similar genomic organization and encode transforming Tax oncoproteins. In contrast to HTLV-2 and 4, HTLV-1 and 3 Tax proteins contain a PSD-95/Drosophila Discs Large/Zona Occludens-I (PDZ) binding motif at their C-terminal that has been shown to play crucial roles in the distinct transforming properties of the Tax proteins. To systematically investigate PDZ-containing proteins roles in HTLV-1 biology, we initiated a global interactome network analysis of Tax and associated human PDZ-containing proteins. This was accomplished through the use of our framework of binary interactome mapping that includes stringent yeast two hybrid and pulldown screening, systematic retesting by protein complementation assay and evaluation of PDZ gene expression in T lymphocytes.
Research center :
Giga-Signal Transduction - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Blibek, Karim ;  Université de Liège - ULiège > GIGA - Membres
Fujii, Naoaki
Legros, Sebastien
Boxus, Mathieu
Dewulf, Jean-François
Zimmermann, Pascale
Kettmann, Richard ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Dequiedt, Franck  ;  Université de Liège - ULiège > GIGA-Research
Twizere, Jean-Claude  ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Language :
English
Title :
Inhibition of Tax transformation activity using a small molecule targetting Tax/PDZ domain interactions.
Alternative titles :
[en] Inhibition de l'activité transformante de Tax avec une petite molecule ciblant les interactions Tax/PDZ.
Publication date :
29 June 2013
Number of pages :
A1
Event name :
16th International Conference on Human Retrovirology: HTLV and Related Viruses HTLV
Event organizer :
Université de Montréal
Université du Québec à Montréal-UQAM
Event place :
Montréal, Québec., Canada
Event date :
du 26 Juin au 30 Juin 2013.
By request :
Yes
Audience :
International
Name of the research project :
Etude du rôle des protéines à domaines PDZ dans l'infection et la transformation des lymphocytes T par le virus de la leucémie humaine HTLV-1.
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
ULiège - Université de Liège [BE]
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since 05 September 2013

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