Article (Scientific journals)
Trabectedine (ET-743/Yondelis) dans le traitement des sarcomes des tissus mous et du cancer de l'ovaire.
GENNIGENS, Christine; Jerusalem, Guy
2011In Revue Médicale de Liège, 66 (7-8), p. 452-5
Peer reviewed
 

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Keywords :
Antineoplastic Agents, Alkylating/pharmacology/therapeutic use; Clinical Trials as Topic; Dioxoles/pharmacology/therapeutic use; Female; Humans; Ovarian Neoplasms/drug therapy; Sarcoma/drug therapy; Soft Tissue Neoplasms/drug therapy; Tetrahydroisoquinolines/pharmacology/therapeutic use
Abstract :
[en] Soft tissue sarcomas account for 1% of all malignant tumours. Until a few years ago, doxorubicine and ifosfamide were the only active chemotherapy drugs in the metastatic setting. Recently, a new drug has proven its efficacy after failure of standard treatments: the trabectedin; its activity is based on interference with ADN repair mechanisms. Trabectedin has just been also validated and reimbursed in patients with ovarian cancer, in partially sensitive recurrence. In this paper, we will review the mechanism of action and the clinical results of trabectedin.
Disciplines :
Oncology
Author, co-author :
GENNIGENS, Christine  ;  Centre Hospitalier Universitaire de Liège - CHU > Oncologie médicale
Jerusalem, Guy  ;  Université de Liège - ULiège > Département des sciences cliniques > Oncologie
Language :
French
Title :
Trabectedine (ET-743/Yondelis) dans le traitement des sarcomes des tissus mous et du cancer de l'ovaire.
Alternative titles :
[en] Trabectedin (ET-743/Yondelis) for treating soft tissue sarcomas and ovarian cancer
Publication date :
2011
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
66
Issue :
7-8
Pages :
452-5
Peer reviewed :
Peer reviewed
Available on ORBi :
since 10 August 2013

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