[en] Human T-cell leukemia virus type 1 (HTLV-1) retrovirus encodes for the Tax protein, which has a transforming capacity in vitro. Tax contains at its C-terminus a binding motif for PDZ domain-containing proteins (PSD95-DLG1-ZO1). It has been shown that the C-terminal motif of Tax is involved in Tax oncogenic capacity. Ten different PDZ domain-containing proteins have been reported to interact with Tax, but the specificity of Tax-human PDZome interactions has not been investigated. The objective of this study is to obtain a comprehensive interactome map for Tax and the human PDZome and to determine a global role of Tax-PDZ interactions in HTLV-1 biology.
Research center :
Giga-Signal Transduction. GIGA-Research
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Blibek, Karim ; Université de Liège - ULiège > GIGA-Research > Protein signaling and interactions > phD student 4th year
Rambout, Xavier ; Université de Liège - ULiège > GIGA-Research > Protein signaling and interactions
beaufays, Jérôme; Université de Liège - ULiège > Chimie et bio-industries > Biophysique moléc. numér.
Lins, Laurence ; Université de Liège - ULiège > Chimie et bio-industries > Biophysique moléc. numér.
Dequiedt, Franck ; Université de Liège - ULiège > GIGA-Research > Protein signaling and interactions
Twizere, Jean-Claude ; Université de Liège - ULiège > GIGA-Research > Protein signaling and interactions
Language :
English
Title :
An interaction map for HTLV-1 Tax and PDZ-containing proteins.
Alternative titles :
[en] Carte interactomique entre l’oncoprotéine Tax du virus HTLV-1 et les protéines à domaines PDZ.
Publication date :
29 June 2013
Number of pages :
A1
Event name :
16th International Conference on Human Retrovirology : HTLV and Related Viruses.
Event organizer :
Université de Montréal Université du Québec à Montréal-UQAM
Event place :
Montréal, Québec., Canada
Event date :
du 26 Juin au 30 Juin 2013.
By request :
Yes
Audience :
International
Name of the research project :
Etude du rôle des protéines à domaines PDZ dans l'infection et la transformation des lymphocytes T par le virus de la leucémie humaine HTLV-1.
Funders :
ULiège - Université de Liège [BE] F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE] FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
