Poster (Scientific congresses and symposiums)
Disruption of PDZ protein-protein interactions inhibits Tax transformation and HTLV-1 infection capacities.
Twizere, Jean-Claude; DEWULF, Jean-François; Blibek, Karim et al.
201115th International Conference on Human Retrovirology: HTLV and Related Retroviruses
 

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Keywords :
MAP; INTERACTION; TAX; PDZ; HTLV-1
Abstract :
[en] Human T-cell leukemia virus type I (HTLV-1) encodes a Tax oncoprotein that is critical for both viral replication and cellular transformation. HTLV-1 Tax possesses a PDZ domain binding motif (PBM) at its C-terminus that is essential for its transforming activity in a Rat-1 model and for IL-2. Tax has been shown to interact with several PDZ domain containing proteins including PSD-95, Beta1-syntrophin, the precursor of interleukin-16, the mammalian homolog of the Drosophila discs large tumor suppressor protein Dlg, PDLIM2, Lin7, hTid1, Tip1, hScrib and MAGI3. In the 15th International Conference on Human Retrovirology: HTLV and Related Retroviruses, we will present a specificity map for the Tax/PDZ domain interactions generated using the human ORFeome 5.1. and we will focus on some of the new Tax/PDZ interactions.
Research center :
Laboratoire de biologie cellulaire et moléculaire Gembloux Agro Bio-Tech
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Twizere, Jean-Claude  ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
DEWULF, Jean-François
Blibek, Karim ;  Université de Liège - ULiège > GIGA - Membres
Legros, Sebastien
Boxus, Mathieu 
Zimmermann, Pascale
FUJII, Naoaki
Kettmann, Richard ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Language :
English
Title :
Disruption of PDZ protein-protein interactions inhibits Tax transformation and HTLV-1 infection capacities.
Alternative titles :
[fr] Carte de spécificité d'interactions entre les protéines à domaines PDZ et l'oncoprotéine Tax du virus HTLV-1.
Publication date :
06 June 2011
Number of pages :
A1
Event name :
15th International Conference on Human Retrovirology: HTLV and Related Retroviruses
Event organizer :
Katholieke Universiteit Leuven (KU Leuven)
Gembloux Agro Bio-tech, Université de Liège
Event place :
Leuven, Gembloux, Belgium
Event date :
du 04 au 08 Juin 2011
By request :
Yes
Audience :
International
Name of the research project :
Etude du rôle des protéines à domaines PDZ dans l'infection et la transformation des lymphocytes T par le virus de la leucémie humaine HTLV-1.
Funders :
Centre universitaire de Recherches agronomiques de Gembloux (CURAGx)
Available on ORBi :
since 05 August 2013

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