Paper published in a journal (Scientific congresses and symposiums)
Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models.
Sainvitu, Pauline; Nasir, Mehmet Nail; Nott, Katherine et al.
2013In World Academy of Science, Engineering and Technology, 77, p. 840
 

Files


Full Text
Poster Amsterdam_P Sainvitu_ok.pdf
Publisher postprint (193 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Aromatic glycolipids; membrane models; antioxidant; monolayer models
Abstract :
[en] Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic). Moreover, they are expected to have interesting antioxidant properties when they contain phenolic groups. The alkyl chain should enhance their ability to penetrate into the cellular membrane (Nicolosi, 2002, Journal of Molecular Catalysis B: Enzymatic). The presence of a sugar unit could also be useful to target specific cells. In this study, novel aromatic glycolipids were synthesized as useful models for studying the structure–activity relationship, in particular as a function of their aromatic group. Their interaction with membranes was studied with monolayer models and was predicted by a computational approach. The relationships between these data and their cytotoxicity and antioxidant properties evaluated on cell cultures are discussed.
Disciplines :
Biochemistry, biophysics & molecular biology
Chemistry
Author, co-author :
Sainvitu, Pauline ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Nasir, Mehmet Nail ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Nott, Katherine ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Lins, Laurence  ;  Université de Liège - ULiège > Chimie et bio-industries > Biophysique moléc. numér.
Crowet, Jean-Marc ;  Université de Liège - ULiège > Chimie et bio-industries > Biophysique moléc. numér.
Willems, Luc  ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Cosse, Jean-Philippe ;  Université de Liège - ULiège > GIGA-R : Epigénétique Cellulaire et Moléculaire
Jérôme, Christine  ;  Université de Liège - ULiège > Département de chimie (sciences) > Centre d'études et de rech. sur les macromolécules (CERM)
Deleu, Magali  ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Language :
English
Title :
Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models.
Alternative titles :
[fr] Caractérisation biophysique des interactions de nouveaux surfactants aromatiques glycolipidiques avec des membranes modèles.
Publication date :
May 2013
Event name :
ICBCBBE 2013 : International Conference on Bioinformatics,Computational Biology and Biomedical Engineering
Event organizer :
World Academy of Science, Engineering and Technology
Event place :
Amsterdam, Netherlands
Event date :
15-16 mai 2013
Audience :
International
Journal title :
World Academy of Science, Engineering and Technology
ISSN :
2010-376X
eISSN :
2010-3778
Publisher :
World Academy of Science Engineering and Technology, France
Volume :
77
Pages :
840
Available on ORBi :
since 15 July 2013

Statistics


Number of views
47 (20 by ULiège)
Number of downloads
53 (6 by ULiège)

Bibliography


Similar publications



Contact ORBi