Poster (Scientific congresses and symposiums)
Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models.
Sainvitu, Pauline; Nasir, Mehmet Nail; Draguet, Florian et al.
2013ICBCBBE 2013 : International Conference on Bioinformatics, Computational Biology and Biomedical Engineering
 

Files


Full Text
Poster Amsterdam_P Sainvitu_ok.pdf
Author postprint (193 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Aromatic glycolipids; monolayer models; membrane models; antioxidant
Abstract :
[en] Aromatic glycolipids are of both medical and pharmaceutical interest. Antimicrobial, antiviral and anti-inflammatory activities have been reported (Otto, 2000, Journal of Molecular Catalysis B: Enzymatic). Moreover, they are expected to have interesting antioxidant properties when they contain phenolic groups. The alkyl chain should enhance their ability to penetrate into the cellular membrane (Nicolosi, 2002, Journal of Molecular Catalysis B: Enzymatic). The presence of a sugar unit could also be useful to target specific cells. In this study, novel aromatic glycolipids were synthesized as useful models for studying the structure–activity relationship, in particular as a function of their aromatic group. Their interaction with membranes was studied with monolayer models and was predicted by a computational approach. The relationships between these data and their cytotoxicity and antioxidant properties evaluated on cell cultures are discussed.
Disciplines :
Chemistry
Biochemistry, biophysics & molecular biology
Author, co-author :
Sainvitu, Pauline ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Nasir, Mehmet Nail ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Draguet, Florian
Nott, Katherine ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Lins, Laurence  ;  Université de Liège - ULiège > Chimie et bio-industries > Biophysique moléc. numér.
Crowet, Jean-Marc ;  Université de Liège - ULiège > Chimie et bio-industries > Biophysique moléc. numér.
Willems, Luc  ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Cosse, Jean-Philippe ;  Université de Liège - ULiège > GIGA-R : Epigénétique Cellulaire et Moléculaire
Jérôme, Christine  ;  Université de Liège - ULiège > Département de chimie (sciences) > Centre d'études et de rech. sur les macromolécules (CERM)
Deleu, Magali  ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Language :
English
Title :
Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models.
Alternative titles :
[fr] Caractérisation biophysique des interactions de nouveaux surfactants aromatiques glycolipidiques avec des membranes modèles.
Publication date :
15 May 2013
Number of pages :
A0
Event name :
ICBCBBE 2013 : International Conference on Bioinformatics, Computational Biology and Biomedical Engineering
Event organizer :
World Academy of Science, Engineering and Technology (WASET)
Event place :
Amsterdam, Netherlands
Event date :
15-16 mai 2013
Audience :
International
Available on ORBi :
since 15 July 2013

Statistics


Number of views
43 (6 by ULiège)
Number of downloads
20 (4 by ULiège)

Bibliography


Similar publications



Contact ORBi