Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry Materials science & engineering
Author, co-author :
Tian, Dong; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Dubois, Philippe ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Grandfils, Christian ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Robert ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Viville, P.; University of Mons-Hainaut (UMH) > Service de Chimie des Matériaux Nouveaux, Centre de Recherche en Electronique et Photonique Moléculaires
Lazzaroni, Roberto; University of Mons-Hainaut (UMH) > Service de Chimie des Matériaux Nouveaux, Centre de Recherche en Electronique et Photonique Moléculaires
Brédas, Jean-Luc; University of Mons-Hainaut (UMH) > Service de Chimie des Matériaux Nouveaux, Centre de Recherche en Electronique et Photonique Moléculaires
Leprince, Pierre ; Université de Liège - ULiège > Department of Human Physiology and Physiopathology
Language :
English
Title :
A novel biodegradable and biocompatible ceramer prepared by the sol-gel process
Williams, D. F., Ed. Definitions in Biomaterials; Elsevier: Amsterdam, 1987; Vol. 4.
Hench, L. L. J. Am. Ceram. Soc. 1992, 74, 1487.
Pitt, C. G.; Marks, T. A.; Schindler, A. Biodegradable Drug Delivery Systems based on Aliphatic Polyesters: Application of Contraceptives and Narcotic Antagonists, in Controlled Release of Bioactive Materials; Baker, R., Ed.; Academic Press: New York, 1980.
Tian, D.; Dubois, Ph.; Jerome, R. Polymer 1996, 37, 3983.
Novak, B. M. Adv. Mater. 1993, 5 (No. 6), 422.
PCL/TEOS mixtures of various compositions were dissolved in THF (20 wt %) and hydrolyzed with a stoichiometric amount of water with respect to the alkoxide functions. HCl was used as a catalyst in a 0.05/1 HC1/TEOS molar ratio. A representative synthesis was as follows: 1.5 g of TEOS was added to the α,ω-triethoxysilane PCL (0.5 g, Mn = 2000) solution in THF (10.0 mL) and thoroughly mixed until a homogeneous solution was formed. Then deionized water (0.54 mL), ethanol (0.80 mL), and HCl (0.01 mL) were added under rapid stirring at ambient temperature for ca. 10 min. The clear solution was then cast into a plastic Petri dish and covered with a Parafilm. Based on a preliminary series of gelation experiments it was shown that after a few days depending on the PCL end-groups (hydroxyl or triethoxysilane) the Parafilm was to be removed. The gelified material was then dried under ambient condition for 1 week and finally cured at 100 °C for 2 days prior to testing.
Contact angles (θ) were measured with a home-built equipment according to the Mack indirect method.8 θ was calculated as θ = 2 arctan(2h/d), where d and h are the diameter and height of the water droplet, respectively.
(a) Mack, G. L.; J. Phys. Chem. 1936, 40, 159.
(b) Wu, S. Polymer Interface and Adhesion; Marcel Dekker: New York, 1982.
Magonov, S. N.; Whangbo, M.-H. In Surface Analysis with STM and AFM: Experimental and Theoretical Aspects of Image Analysis; VCH: New York, 1996; pp 37-39.
Tian, D. Ph.D. Thesis, University of Liège, Belgium, 1997.
Elgendy, H. M.; Norwan, M. E.; Keaton, A. R.; Lawencin, C. T. Biomaterials 1993, 14, 263.