Reference : Characterization and optimization of GMO-based gels with long term release for intraarti...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/152738
Characterization and optimization of GMO-based gels with long term release for intraarticular administration
English
Réeff, J. [Université Libre de Bruxelles (ULB) > Laboratory of Pharmaceutics and Biopharmaceutics > > >]
Gaignaux, A. [Université Libre de Bruxelles (ULB) > Laboratory of Pharmaceutics and Biopharmaceutics > > >]
Goole, J. [Université Libre de Bruxelles (ULB) > Laboratory of Pharmaceutics and Biopharmaceutics > > >]
Siepmann, J. [University of Lille, France > College of Pharmacy > INSERM U 1008 > >]
Siepmann, F. [University of Lille, France > College of Pharmacy > INSERM U 1008 > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Thomassin, Jean-Michel [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
De Vriese, C. [Université Libre de Bruxelles (ULB) > Laboratory of Pharmaceutics and Biopharmaceutics > > >]
Amighi, K. [Université Libre de Bruxelles (ULB) > Laboratory of Pharmaceutics and Biopharmaceutics > > >]
15-Jul-2013
International Journal of Pharmaceutics
Elsevier Science
451
1-2
95-103
Yes (verified by ORBi)
International
0378-5173
Amsterdam
The Netherlands
[en] biomaterial ; nanomedicine
[en] Osteoarthritis is characterized by slow degenerative processes in the articular cartilage within synovial joints. It could be interesting to develop a sustained-release formulation that could be effective on both pain/inflammation and restoration of mechanical integrity of the joint. Recently, an injectable system based on glycerol monooleate (GMO), containing clonidine as a model hydrophilic analgesic/anti-inflammatory drug and hyaluronic acid as a viscoelastic scaffold, showed promising potential as a biodegradable and biocompatible preparation to sustain the drug activity. However, drug release from the system is relatively fast (complete within 1 week) and the underlying drug release mechanisms not fully understood. The aims of this study were: (i) to significantly improve this type of local controlled drug delivery system by further sustaining clonidine release, and (ii) to elucidate the underlying mass transport mechanisms. The addition of FDA-approved inactive ingredients such as sodium oleate or purified soybean oil was found to be highly effective. The release rate could be substantially reduced (e.g., 50% release after 10 days), due to the increased hydrophobicity of the systems, resulting in slower and reduced water uptake and reduced drug mobility. Interestingly, Fick's second law of diffusion could be used to quantitatively describe drug release.
Center for Education and Research on Macromolecules (CERM)
Researchers
http://hdl.handle.net/2268/152738
http://dx.doi.org/10.1016/j.ijpharm.2013.04.079
http://www.sciencedirect.com/science/article/pii/S0378517313003906

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