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Magnetic hybrid materials for triggered drug delivery and optical properties of intraocular lens
Liu, Ji; Jérôme, Christine; Detrembleur, Christophe et al.
2013The International Doctoral School in Functional Materials (IDS-FunMat) Training School
 

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Keywords :
biomaterial; nanomedicine; silica nanoparticle
Abstract :
[en] Mesoporous silica nanoparticles have great potential for drug delivery system (DDS) due to their large volume for encapsulation of guest molecules in the porous channels. Due to the specific magnetic responsiveness, magnetic nanoparticles can penetrate body tissues under a magnetic guidance, providing a potential platform for magnetic-directed DDS. Furthermore, a sharp local heating can be obtained for superparamagnetic nanoparticles when exposed to an alternating magnetic field (AMF). This specific property opens up the possibility of the application in tumor treatments. Here, we fabricated maghemite/SiO2 mesoporous nanohybrids DDS with phase-changed molecules as gate-keepers. The channels were envisaged to be closed in the biological systems during the delivery; however, opened when exposed to external heating or internal heating from hyperthermia generated by the maghemite cores. Thus the uploaded drug can diffuse into the surrounding medium. MTS assay showed a good cytocompatibility of the vehicles in both mouse L929 cells and cancer MEL-5 cells, and also internalization into MEL-5 cells was confirmed by Fluoresce microscopy, fluoresce-activated cell sorting (FACS) and TEM techniques. The release of drugs can be controlled by varying the concentration of the nanohybrids vehicles, the period of AMF treatment, or both. In-vivo triggered-release of doxorubicin into MEL-5 cells was confirmed by the sharp decrease in cell viability. This DDS can be designed for controlled release to an urgent physiological need via chemotherapy, hyperthermia therapy, or both.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Materials science & engineering
Chemistry
Author, co-author :
Liu, Ji ;  Université de Liège - ULiège and University of Bordeaux 1, CNRS > Department of Chemistry of Liège, Institut de Chimie de la Matiere Condense de Bordeaux > Center for Education and Research on Macromolecules (CERM)
Jérôme, Christine  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Detrembleur, Christophe ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Duguet, Etienne;  University of Bordeaux 1, CNRS > Institut de Chimie de la Matiere Condense de Bordeaux
Mornet, Stéphane;  University of Bordeaux 1, CNRS > Institut de Chimie de la Matiere Condense de Bordeaux
Language :
English
Title :
Magnetic hybrid materials for triggered drug delivery and optical properties of intraocular lens
Publication date :
20 March 2013
Event name :
The International Doctoral School in Functional Materials (IDS-FunMat) Training School
Event organizer :
The University of Bordeaux 1
Event place :
Annecy, France
Event date :
17/03/2013 - 22/03/2013
Audience :
International
Funders :
IDS-FUNMAT
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Commentary :
This oral communication was presented by Ji Liu
Available on ORBi :
since 05 July 2013

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