Article (Scientific journals)
The inhibition of metalloproteinases to treat osteoarthritis: reality and new perspectives
Henrotin, Yves; Sanchez, Christelle; Reginster, Jean-Yves
2002In Expert Opinion on Therapeutic Patents, 12 (1), p. 29-43
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Keywords :
cartilage; inhibitors; metalloproteinases; osteoarthritis
Abstract :
[en] The objective of this paper is to analyse the potential therapeutic action of MMP inhibitors in the management of osteoarthritis (OA), based on a critical review of the literature. The role played by metalloproteinases (MPs) in the pathophysiology of osteoarthritis is discussed, as well as their regulation by tissular inhibitors, activators and cytokines. The evidences that commonly used drugs for treating osteoarthritis are also active on MPs synthesis is also reported. Finally, this paper provides an analysis of the recent patents published with promising therapeutic potential and gives new perspectives for anti-MPs therapy.
Disciplines :
Pharmacy, pharmacology & toxicology
Rheumatology
Author, co-author :
Henrotin, Yves  ;  Université de Liège - ULiège > Unité de recherche sur l'os et le cartillage (U.R.O.C.)
Sanchez, Christelle  ;  Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Language :
English
Title :
The inhibition of metalloproteinases to treat osteoarthritis: reality and new perspectives
Publication date :
January 2002
Journal title :
Expert Opinion on Therapeutic Patents
ISSN :
1354-3776
eISSN :
1744-7674
Publisher :
Ashley Publications Ltd, London, United Kingdom
Volume :
12
Issue :
1
Pages :
29-43
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 November 2008

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