Article (Scientific journals)
The immune system as a foundation for immunologic therapy and hematologic malignancies: a historical perspective.
Baron, Frédéric; Storb, Rainer
2006In Best Practice and Research. Clinical Haematology, 19 (4), p. 637-53
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Keywords :
Hematologic Neoplasms/immunology/therapy; Humans; Immune System/immunology; Immunotherapy/methods/trends
Abstract :
[en] In this review we aim to provide a historical overview of the immunotherapeutic approaches which have been developed for the treatment of hematological malignancies. After briefly summarizing the development of the theory of cancer immune surveillance, we describe how initial studies discovering the efficacy of the immune-mediated graft-versus-tumor effects after allogeneic hematopoietic cell transplantation led to new transplantation approaches (termed non-myeloablative transplantation) relying almost exclusively on graft-versus-tumor effects for tumor eradication. We then summarize important steps in the development of tumor vaccines and autologous adoptive immunotherapy in patients with hematological malignancies. Finally, we describe historical discoveries leading to the recent success with monoclonal antibodies as treatment for lymphomas, chronic lymphocytic leukemia, and acute myeloid leukemia.
Disciplines :
Hematology
Author, co-author :
Baron, Frédéric  ;  Université de Liège - ULiège > Département des sciences cliniques > GIGA-R : Hématologie - Département des sciences cliniques
Storb, Rainer
Language :
English
Title :
The immune system as a foundation for immunologic therapy and hematologic malignancies: a historical perspective.
Publication date :
2006
Journal title :
Best Practice and Research. Clinical Haematology
ISSN :
1521-6926
eISSN :
1532-1924
Publisher :
Bailliere Tindall, London, United Kingdom
Volume :
19
Issue :
4
Pages :
637-53
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 June 2013

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