No full text
Article (Scientific journals)
Early thalamic and cortical hypometabolism in adult-onset dementia due to metachromatic leukodystrophy
Salmon, Eric; Van der Linden, Martial; Maertens De Noordhout, Alain et al.
1999In Acta Neurologica Belgica, 99 (3), p. 185-188
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Keywords :
positron emission tomography; dementia; metachromatic leukodystrophy
Abstract :
[en] A case of early-onset adult dementia with family history of dementia is reported, characterised by neuropsychological deficits, suggesting frontal involvement, with mild non specific white matter abnormalities on CT scan. Familial Alzheimer's disease was suspected but the neuropathological diagnosis on brain biopsy was metachromatic leukodystrophy. 18FDG-PET revealed a very peculiar pattern of metabolic impairment in thalamic areas, in medial and frontopolar regions, and in occipital lobes. Neuropsychological follow-up showed relatively stable difficulties of long-term memory and signs of frontal lobe dysfunction, similar to those observed in subcortical dementias. MRI subsequently showed periventricular leukoencephalopathy. The brain metabolic pattern observed in that case of metachromatic leukodystrophy was quite different from that reported in other types of dementia.
Disciplines :
Neurology
Author, co-author :
Salmon, Eric  ;  Université de Liège - ULiège > Centre de Recherches du Cyclotron - Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Van der Linden, Martial ;  Université de Liège - ULiège > Département des sciences cognitives > Psychopathologie cognitive
Maertens De Noordhout, Alain  ;  Université de Liège - ULiège > Neurologie CHR
Brucher, J. M.
Mouchette, R.
Waltregny, A.
Degueldre, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Franck, Georges ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Early thalamic and cortical hypometabolism in adult-onset dementia due to metachromatic leukodystrophy
Publication date :
September 1999
Journal title :
Acta Neurologica Belgica
ISSN :
0300-9009
eISSN :
2240-2993
Publisher :
Acta Medica Belgica, Brussels, Belgium
Volume :
99
Issue :
3
Pages :
185-188
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FMRE - Fondation Médicale Reine Elisabeth [BE]
Available on ORBi :
since 03 January 2010

Statistics


Number of views
71 (17 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
7
Scopus citations®
without self-citations
7

Bibliography


Similar publications



Contact ORBi