Poster (Scientific congresses and symposiums)
Development of a quantitative approach to measure phospholipids in dried drops by Raman spectroscopy
Malherbe, Cédric; Jadoul, Laure; Gilbert, Bernard et al.
2013RamanFest Symposium 2013
 

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Keywords :
quantitative; Raman spectroscopy; phospholipids
Abstract :
[en] Phospholipids, PL, such as the phosphatidylcholine PC(18:0/18:1), play a role in the structure of living cells and are suspected to be part of the development of some diseases, for example cancers. Mass spectrometry enables the structural analysis of PL in complex biological media but imaging mass spectrometry by MALDI-MS is rather limited for quantification purposes. Complementarily, Raman spectroscopy as a non invasive and non destructive method is a potential candidate to quantify and visualise the spatial distribution of the PL by molecular imaging. Unfortunately, the lack of specific chemical function in PL, compared to others biomolecules, limits the use of Raman spectroscopy in the identification process of those PL in complex biological samples. The results presented here belong to a first study of the application of the Raman analyses on dried residues of PL and mice brain tissue performed in the lab.
Disciplines :
Chemistry
Author, co-author :
Malherbe, Cédric ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique et électrochimie
Jadoul, Laure ;  Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)
Gilbert, Bernard ;  Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences)
De Pauw, Edwin  ;  Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)
Eppe, Gauthier  ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique
Language :
English
Title :
Development of a quantitative approach to measure phospholipids in dried drops by Raman spectroscopy
Publication date :
24 May 2013
Event name :
RamanFest Symposium 2013
Event organizer :
O. Hirsch
Event place :
Lille, France
Event date :
du 23 au 27 mai 2013
Audience :
International
Available on ORBi :
since 21 June 2013

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