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Impact of strenuous exercise on the release of cardiac biomarkers
LE GOFF, Caroline; MELON, Pierre; Kaux, Jean-François et al.
2013In Biochimica Clinica, 37 (SS), p. 545
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Abstract :
[en] Background: Cardiac troponins (cTn) are considered as the best biomarkers for detection of myocardial cell injury and NT-proBNP as the best for the cardiac insufficiency. In this study, cTnT was measured by new commercially available high-sensitive methods in subjects un-dergoing the Maasmarathon. Our aim was to compare cTnT and NT-proBNP levels before and after the stress tests, in sportive subjects. Methods: Twenty eight subjects (26 ♂, 42.5±11yo) underwent a race of 42.195 kilometers be-tween Visé (Belgium) and Maastricht (The Netherlands). We drowned blood sample before (T0), just after (T1) and three hours after the race (T3). In all patients, cTnT concentrations were measured by high sensitive methods (hsTnT, Roche Diagnostics) on heparin plasma. The NT-proBNP was also determined with the kit Roche on heparin plasma. The protocol was approved by the ethics committee of the University of Liège (Belgium). All subjects gave their informed consent. All statistical analyses were performed using Medcalc version 8.1 for Windows. p-value <0.01 was regarded as statistically significant. Results: There was a significant difference between hsTnT concentrations at T0 and T1 (p<0.0001), and between T0 and T3 (p<0.001) for NT-proBNP, but not between T1 and T3. This observation appeared only after a strenuous exercise but today this type of exercise is not reproduce easier in a laboratory of sport. Moreover, at this moment, nobody knows if these observations would have cardiac consequences at long terms. Conclusions: Measurement of cardiac troponins by high sensitive methods allows detecting significant release of biomarkers from the heart during exercise. The value of NT-proBNP are also significant but less than TnThs. We think that the TnThs could be an interesting tool in the future to help sport medicine to detect risk of developing a cardiac problem in the future or a sudden death.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
LE GOFF, Caroline  ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
MELON, Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Cardiologie
Kaux, Jean-François  ;  Université de Liège - ULiège > Département des sciences de la motricité > Département des sciences de la motricité
Fillet, Marianne ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
CHAPELLE, Jean-Paul ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Cavalier, Etienne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Impact of strenuous exercise on the release of cardiac biomarkers
Publication date :
May 2013
Event name :
Euromedlab 2013
Event place :
Milan, Italy
Event date :
19-23 May 2013
Audience :
International
Journal title :
Biochimica Clinica
ISSN :
0393-0564
Publisher :
CLAS International, Italy
Volume :
37
Issue :
SS
Pages :
S545
Peer reviewed :
Peer reviewed
Available on ORBi :
since 19 June 2013

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