Reference : The Penicillin-Binding Proteins: Structure and Role in Peptidoglycan Biosynthesis
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/15052
The Penicillin-Binding Proteins: Structure and Role in Peptidoglycan Biosynthesis
English
Sauvage, Eric* mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Kerff, Frédéric* mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Terrak, Mohammed mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Ayala, J. A. [> > > >]
Charlier, Paulette mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
* These authors have contributed equally to this work.
Mar-2008
FEMS Microbiology Reviews
32
2
234-58
Yes (verified by ORBi)
International
0168-6445
[en] Penicillin-binding proteins (PBPs) have been scrutinized for over 40 years. Recent structural information on PBPs together with the ongoing long-term biochemical experimental investigations, and results from more recent techniques such as protein localization by green fluorescent protein-fusion immunofluorescence or double-hybrid assay, have brought our understanding of the last stages of the peptidoglycan biosynthesis to an outstanding level that allows a broad outlook on the properties of these enzymes. Details are emerging regarding the interaction between the peptidoglycan-synthesizing PBPs and the peptidoglycan, their mesh net-like product that surrounds and protects bacteria. This review focuses on the detailed structure of PBPs and their implication in peptidoglycan synthesis, maturation and recycling. An overview of the content in PBPs of some bacteria is provided with an emphasis on comparing the biochemical properties of homologous PBPs (orthologues) belonging to different bacteria.
http://hdl.handle.net/2268/15052
10.1111/j.1574-6976.2008.00105.x

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