No document available.
Abstract :
[en] Background: The use of porous titanium particles as space
filling biomaterials for intraoral bone regeneration might be of
interest because of both the mechanical stability and nonresorbable
properties. Titanium particles were recently described for
bone regeneration in sinus lifts and in the treatment of periimplantitis.
Nevertheless, tissue integration and 3D bone regeneration
with titanium particles were poorly explored in these
previous reports.
Aim: The first objective of this study was to qualitatively and
quantitatively assess the bone formation process, particularly
the long-term behavior and 3D volume stability of subsinusal
bone regeneration, using titanium or bovine hydroxyapatite
granules, in a rabbit model. The second objective was to
evaluate the effect of the hydration of the BHA particles with
a therapeutic concentration of doxycycline solution on the
osteogenesis and biomaterial resorption.
Methods: Rabbits underwent a double sinus lift procedure
using one of three materials: grade 1 porous titanium particles
(Ti), bovine hydroxyapatite (BHA) or chemically modified bovine
hydroxyapatite (BHATTC). Animals were sacrificed after 1
week, 5 weeks or 6 months. Samples were analyzed using mCT
and nondecalcified histology.
Results: The materials used in each of the three groups allowed
an optimal bone formation; bone quantities and densities were
not statistically different between the three groups. At 6
months, more stable 3D volume stability was found with TI
and BHATTC (P¼0.0033). At 5 weeks and 6 months, bone to
material contact (BMC) corroborating osteoconduction was significantly
higher with BHA and BHATTC than with Ti
(P < 0.0001).
Conclusions and clinical implications: Even though the studied
biomaterials displayed different architectures, they are relevant
candidates for sinus lift bone augmentation before dental implants
because they allow adequate 3D stability and osteogenesis.
However, to recommend the clinical use of Ti, both an
observation on the drilling effects of Ti particles and clinical
trials are needed.
