Article (Scientific journals)
Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development
Manfroid, Isabelle; Delporte, F.; Baudhuin, A. et al.
2007In Development, 134 (22), p. 4011-21
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Keywords :
Animals; Animals, Genetically Modified; Cell Communication/physiology; Cell Differentiation; Embryo, Nonmammalian; Endoderm/metabolism/*physiology; Fibroblast Growth Factors/genetics/*physiology; Gene Expression Regulation, Developmental; Homeodomain Proteins/genetics/metabolism; Mesoderm/metabolism/*physiology; Models, Biological; Organ Specificity; Pancreas/*embryology/metabolism; Signal Transduction/genetics; Zebrafish/embryology; Zebrafish Proteins/genetics/metabolism/*physiology
Abstract :
[en] In amniotes, the pancreatic mesenchyme plays a crucial role in pancreatic epithelium growth, notably through the secretion of fibroblast growth factors. However, the factors involved in the formation of the pancreatic mesenchyme are still largely unknown. In this study, we characterize, in zebrafish embryos, the pancreatic lateral plate mesoderm, which is located adjacent to the ventral pancreatic bud and is essential for its specification and growth. We firstly show that the endoderm, by expressing the fgf24 gene at early stages, triggers the patterning of the pancreatic lateral plate mesoderm. Based on the expression of isl1, fgf10 and meis genes, this tissue is analogous to the murine pancreatic mesenchyme. Secondly, Fgf10 acts redundantly with Fgf24 in the pancreatic lateral plate mesoderm and they are both required to specify the ventral pancreas. Our results unveil sequential signaling between the endoderm and mesoderm that is critical for the specification and growth of the ventral pancreas, and explain why the zebrafish ventral pancreatic bud generates the whole exocrine tissue.
Research center :
Giga-Development and Stem Cells - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Manfroid, Isabelle ;  Université de Liège - ULiège > GIGA-Research
Delporte, F.
Baudhuin, A.
Motte, P.
Neumann, C. J.
Voz, Marianne  ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Martial, Joseph ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Peers, Bernard ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Language :
English
Title :
Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development
Publication date :
2007
Journal title :
Development
ISSN :
0950-1991
eISSN :
1477-9129
Publisher :
Company of Biologists, Cambridge, United Kingdom
Volume :
134
Issue :
22
Pages :
4011-21
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 June 2009

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