Reference : Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas de...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/15009
Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development
English
Manfroid, Isabelle mailto [Université de Liège - ULg > > GIGA-Research >]
Delporte, F. [> > > >]
Baudhuin, A. [> > > >]
Motte, P. [> >]
Neumann, C. J. [> > > >]
Voz, Marianne mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Martial, Joseph mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Peers, Bernard mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
2007
Development
Company of Biologists
134
22
4011-21
Yes (verified by ORBi)
International
0950-1991
1477-9129
Cambridge
United Kingdom
[en] Animals ; Animals, Genetically Modified ; Cell Communication/physiology ; Cell Differentiation ; Embryo, Nonmammalian ; Endoderm/metabolism/*physiology ; Fibroblast Growth Factors/genetics/*physiology ; Gene Expression Regulation, Developmental ; Homeodomain Proteins/genetics/metabolism ; Mesoderm/metabolism/*physiology ; Models, Biological ; Organ Specificity ; Pancreas/*embryology/metabolism ; Signal Transduction/genetics ; Zebrafish/embryology ; Zebrafish Proteins/genetics/metabolism/*physiology
[en] In amniotes, the pancreatic mesenchyme plays a crucial role in pancreatic epithelium growth, notably through the secretion of fibroblast growth factors. However, the factors involved in the formation of the pancreatic mesenchyme are still largely unknown. In this study, we characterize, in zebrafish embryos, the pancreatic lateral plate mesoderm, which is located adjacent to the ventral pancreatic bud and is essential for its specification and growth. We firstly show that the endoderm, by expressing the fgf24 gene at early stages, triggers the patterning of the pancreatic lateral plate mesoderm. Based on the expression of isl1, fgf10 and meis genes, this tissue is analogous to the murine pancreatic mesenchyme. Secondly, Fgf10 acts redundantly with Fgf24 in the pancreatic lateral plate mesoderm and they are both required to specify the ventral pancreas. Our results unveil sequential signaling between the endoderm and mesoderm that is critical for the specification and growth of the ventral pancreas, and explain why the zebrafish ventral pancreatic bud generates the whole exocrine tissue.
Giga-Development and Stem Cells
http://hdl.handle.net/2268/15009
2007/10/19

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