Reference : Apoptosis characterizes immunological failure of HIV infected patients
Scientific journals : Article
Human health sciences : Immunology & infectious disease
Engineering, computing & technology : Computer science
http://hdl.handle.net/2268/14942
Apoptosis characterizes immunological failure of HIV infected patients
English
Mhawej, Marie-José [ > > ]
Brunet-Francois, Cécile [ > > ]
Fonteneau, Raphaël mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Ernst, Damien mailto [Université de Liège - ULg > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Ferré, Virginie [ > > ]
Stan, Guy-Bart [ > > ]
Raffi, François [ > > ]
Moog, Claude H. [ > > ]
Jul-2009
Control Engineering Practice
Pergamon Press - An Imprint of Elsevier Science
17
7
798-804
Yes (verified by ORBi)
International
0967-0661
[en] non-linear systems ; identifiability ; parameter estimation ; apoptosis ; HIV ; clinical trial
[en] This paper studies the influence of apoptosis in the dynamics of the HIV infection. A new modeling of the healthy CD4+ T-cells activation-induced apoptosis is used. The parameters of this model are identified by using clinical data generated by monitoring patients starting Highly Active Anti-Retroviral Therapy (HAART). The sampling of blood tests is performed to satisfy the constraints of dynamical system parameter identification. The apoptosis parameter, which is inferred from clinical data, is then shown to play a key role in the early diagnosis of immunological failure.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
http://hdl.handle.net/2268/14942
10.1016/j.conengprac.2009.01.001
http://www.elsevier.com/wps/find/journaldescription.cws_home/123/description#description
http://www.montefiore.ulg.ac.be/~ernst/

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