Article (Scientific journals)
Application of Bayesian Population Physiologically Based Pharmacokinetic (PBPK) Modeling and Markov Chain Monte Carlo Simulations to Pesticide Kinetics Studies in Protected Marine Mammals: DDT, DDE, and DDD in Harbor Porpoises
Weijs, Liesbeth; Yang, Raymond S.H.; Das, Krishna et al.
2013In Environmental Science and Technology, 47, p. 4365-4374
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Keywords :
marine mammals; pollutants; harbour porpoise; DDT; Phocoena phocoena; PBPK; physiologically based pharmacokinetic modeling; Black Sea
Abstract :
[en] Physiologically based pharmacokinetic (PBPK) modeling in marine mammals is a challenge because of the lack of parameter information and the ban on exposure experiments. To minimize uncertainty and variability, parameter estimation methods are required for the development of reliable PBPK models. The present study is the first to develop PBPK models for the lifetime bioaccumulation of p,p′-DDT, p,p′-DDE, and p,p′- DDD in harbor porpoises. In addition, this study is also the first to apply the Bayesian approach executed with Markov chain Monte Carlo simulations using two data sets of harbor porpoises from the Black and North Seas. Parameters from the literature were used as priors for the first “model update” using the Black Sea data set, the resulting posterior parameters were then used as priors for the second “model update” using the North Sea data set. As such, PBPK models with parameters specific for harbor porpoises could be strengthened with more robust probability distributions. As the science and biomonitoring effort progress in this area, more data sets will become available to further strengthen and update the parameters in the PBPK models for harbor porpoises as a species anywhere in the world. Further, such an approach could very well be extended to other protected marine mammals.
Research center :
MARE - Centre Interfacultaire de Recherches en Océanologie - ULiège
Disciplines :
Aquatic sciences & oceanology
Author, co-author :
Weijs, Liesbeth
Yang, Raymond S.H.
Das, Krishna  ;  Université de Liège - ULiège > Département de Biologie, Ecologie et Evolution > Océanologie
Covaci, Adrian
Blust, Ronny
Language :
English
Title :
Application of Bayesian Population Physiologically Based Pharmacokinetic (PBPK) Modeling and Markov Chain Monte Carlo Simulations to Pesticide Kinetics Studies in Protected Marine Mammals: DDT, DDE, and DDD in Harbor Porpoises
Publication date :
2013
Journal title :
Environmental Science and Technology
ISSN :
0013-936X
eISSN :
1520-5851
Publisher :
American Chemical Society, Washington, United States - District of Columbia
Volume :
47
Pages :
4365-4374
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FWO - Fonds Wetenschappelijk Onderzoek Vlaanderen [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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since 27 May 2013

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