Article (Scientific journals)
The H(3) antagonist thioperamide reveals conditioned preference for a context associated with an inactive small dose of cocaine in C57BL/6J mice
Brabant, Christian; Charlier, Yana; Quertemont, Etienne et al.
2005In Behavioural Brain Research, 160 (1), p. 161-168
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Keywords :
cocaine; histamine; H-3 autoreceptors; thioperamide; conditioned place preference; locomotion; C57BL/6J mice
Abstract :
[en] The histaminergic system has been speculated to be involved in the inhibitory control of drug reward, H-1 and H-2 antagonists having been found to potentiate conditioned place preference induced by morphine or cocaine. In contrast, the role of H-3 receptors in cocaine-induced place preference is still unknown. The present study tested the effects of thioperamide (0, 10 and 20 mg/kg, i.p.), an H-3 autoreceptor antagonist, on the development of a conditioned place preference induced by cocaine (0, 2 and 8 mg/kg, i.p.) in C57BL/6J mice. Thioperamide was injected 10 min before each cocaine-pairing session. The activity scores recorded on the first cocaine-pairing session were also used to test the effects of thioperamide on cocaine-induced locomotor activity. Thioperamide alone had no reinforcing effects and did not affect the conditioned place preference induced by 8 mg/kg cocaine. However, thioperamide dose-dependently revealed a conditioned place preference induced by 2 mg/kg cocaine, a dose that was inactive per se. Finally, thioperamide dose-dependently potentiated the stimulant effects of cocaine, in spite of its slight hypolocomotor effect when given alone. Our results strongly suggest that H3 antagonists potentiate the stimulant and reinforcing effects of cocaine in mice. © 2004 Elsevier B.V. All rights reserved.
Research center :
Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Psychiatry
Pharmacy, pharmacology & toxicology
Neurosciences & behavior
Author, co-author :
Brabant, Christian ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Charlier, Yana ;  Université de Liège - ULiège > Département des sciences cognitives > Département des sciences cognitives
Quertemont, Etienne  ;  Université de Liège - ULiège > Département des sciences cognitives > Psychologie quantitative
Tirelli, Ezio ;  Université de Liège - ULiège > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér.
Language :
English
Title :
The H(3) antagonist thioperamide reveals conditioned preference for a context associated with an inactive small dose of cocaine in C57BL/6J mice
Publication date :
2005
Journal title :
Behavioural Brain Research
ISSN :
0166-4328
eISSN :
1872-7549
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
160
Issue :
1
Pages :
161-168
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 28 November 2008

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