ORBi: Brabant Christian - The H(3) antagonist thioperamide reveals conditioned preference for a context associated with an inactive small dose of cocaine in C57BL/6J mice

Reference : The H(3) antagonist thioperamide reveals conditioned preference for a context associated...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Psychiatry Human health sciences : Pharmacy, pharmacology & toxicology Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/1487

Title :	The H(3) antagonist thioperamide reveals conditioned preference for a context associated with an inactive small dose of cocaine in C57BL/6J mice
Language :	English
Author, co-author :	Brabant, Christian [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
	Charlier, Yana [Université de Liège - ULg > Département des sciences cognitives > Département des sciences cognitives >]
	Quertemont, Etienne [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
	Tirelli, Ezio [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
Publication date :	2005
Journal title :	Behavioural Brain Research
Publisher :	Elsevier Science
Volume :	160
Issue/season :	1
Pages :	161-168
Audience :	International
ISSN :	0166-4328
City :	Amsterdam
Country :	The Netherlands
Keywords :	[en] cocaine ; histamine ; H-3 autoreceptors ; thioperamide ; conditioned place preference ; locomotion ; C57BL/6J mice
Abstract :	[en] The histaminergic system has been speculated to be involved in the inhibitory control of drug reward, H-1 and H-2 antagonists having been found to potentiate conditioned place preference induced by morphine or cocaine. In contrast, the role of H-3 receptors in cocaine-induced place preference is still unknown. The present study tested the effects of thioperamide (0, 10 and 20 mg/kg, i.p.), an H-3 autoreceptor antagonist, on the development of a conditioned place preference induced by cocaine (0, 2 and 8 mg/kg, i.p.) in C57BL/6J mice. Thioperamide was injected 10 min before each cocaine-pairing session. The activity scores recorded on the first cocaine-pairing session were also used to test the effects of thioperamide on cocaine-induced locomotor activity. Thioperamide alone had no reinforcing effects and did not affect the conditioned place preference induced by 8 mg/kg cocaine. However, thioperamide dose-dependently revealed a conditioned place preference induced by 2 mg/kg cocaine, a dose that was inactive per se. Finally, thioperamide dose-dependently potentiated the stimulant effects of cocaine, in spite of its slight hypolocomotor effect when given alone. Our results strongly suggest that H3 antagonists potentiate the stimulant and reinforcing effects of cocaine in mice. © 2004 Elsevier B.V. All rights reserved.
Research units :	Centre de Neurosciences Cognitives et Comportementales
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/1487
DOI :	10.1016/j.bbr.2004.11.029

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