Reference : The H(3) antagonist thioperamide reveals conditioned preference for a context associa...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Pharmacy, pharmacology & toxicology
Human health sciences : Psychiatry
http://hdl.handle.net/2268/1487
The H(3) antagonist thioperamide reveals conditioned preference for a context associated with an inactive small dose of cocaine in C57BL/6J mice
English
Brabant, Christian mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
Charlier, Yana mailto [Université de Liège - ULg > Département des sciences cognitives > Département des sciences cognitives >]
Quertemont, Etienne mailto [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
Tirelli, Ezio mailto [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
2005
Behavioural Brain Research
Elsevier Science
160
1
161-168
Yes (verified by ORBi)
International
0166-4328
Amsterdam
The Netherlands
[en] cocaine ; histamine ; H-3 autoreceptors ; thioperamide ; conditioned place preference ; locomotion ; C57BL/6J mice
[en] The histaminergic system has been speculated to be involved in the inhibitory control of drug reward, H-1 and H-2 antagonists having been found to potentiate conditioned place preference induced by morphine or cocaine. In contrast, the role of H-3 receptors in cocaine-induced place preference is still unknown. The present study tested the effects of thioperamide (0, 10 and 20 mg/kg, i.p.), an H-3 autoreceptor antagonist, on the development of a conditioned place preference induced by cocaine (0, 2 and 8 mg/kg, i.p.) in C57BL/6J mice. Thioperamide was injected 10 min before each cocaine-pairing session. The activity scores recorded on the first cocaine-pairing session were also used to test the effects of thioperamide on cocaine-induced locomotor activity. Thioperamide alone had no reinforcing effects and did not affect the conditioned place preference induced by 8 mg/kg cocaine. However, thioperamide dose-dependently revealed a conditioned place preference induced by 2 mg/kg cocaine, a dose that was inactive per se. Finally, thioperamide dose-dependently potentiated the stimulant effects of cocaine, in spite of its slight hypolocomotor effect when given alone. Our results strongly suggest that H3 antagonists potentiate the stimulant and reinforcing effects of cocaine in mice. © 2004 Elsevier B.V. All rights reserved.
Centre de Neurosciences Cognitives et Comportementales
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals
http://hdl.handle.net/2268/1487
10.1016/j.bbr.2004.11.029

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