ORBi: Barakat Ibrahim - Macromolecular engineering of polylactones and polylactides. XXV. Synthesis and characterization of bioerodible amphiphilic networks and their use as controlled drug delivery systems

Reference : Macromolecular engineering of polylactones and polylactides. XXV. Synthesis and characte...


	Document type :	Scientific journals : Article
	Discipline(s) :	Engineering, computing & technology : Materials science & engineering Physical, chemical, mathematical & earth Sciences : Chemistry
	To cite this reference:	http://hdl.handle.net/2268/14844

Title :	Macromolecular engineering of polylactones and polylactides. XXV. Synthesis and characterization of bioerodible amphiphilic networks and their use as controlled drug delivery systems
Language :	English
Author, co-author :	Barakat, Ibrahim [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Dubois, Philippe [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Grandfils, Christian [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Jérôme, Robert [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Publication date :	15-Jul-1999
Journal title :	Journal of Polymer Science. Part A, Polymer Chemistry
Publisher :	John Wiley & Sons
Volume :	37
Issue/season :	14
Pages :	2401-2411
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0887-624X
City :	Hoboken
Keywords :	[en] ring-opening polymerization (ROP) ; lactone ; network
Abstract :	[en] Well-defined ,-methacryloyl poly--caprolactone (PCL) and poly(d,l)-lactide P(D,L)LA dimacromonomers have been synthesized by living ring-opening polymerization of the parent monomers initiated by diethylaluminum 2-hydroxyethylmethacrylate (Et2AlO(CH2)2OC(O)C(CH3)CH2) and terminated by reaction of the propagating Al alkoxide groups with methacryloyl chloride. These dimacromonomers have been copolymerized with a hydrophilic comonomer, i.e., 2-hydroxyethylmethacrylate, in bulk at 65°C by using benzoyl peroxide as a free-radical initiator. The swelling ability of the amphiphilic PHEMA/PCL or P(D,L)LA networks has been investigated in both aqueous and organic media. Effect of network composition and molecular weight of the dimacromonomer on the swelling kinetics and the equilibrium solvent uptake has been studied. Lipophilic dexamethasone acetate and the hydrophilic sodium phosphate counterpart have been incorporated into the amphiphilic gels and their release has been studied in relation to the gel characteristics.
Research units :	Center for Education and Research on Macromolecules (CERM)
Funders :	Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/14844
DOI :	10.1002/(SICI)1099-0518(19990715)37:14<2401::AID-POLA14>3.0.CO;2-9
Other URL :	http://www3.interscience.wiley.com/cgi-bin/fulltext/62003232/PDFSTART

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