Reference : Macromolecular engineering of polylactones and polylactides. XXV. Synthesis and chara...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/14844
Macromolecular engineering of polylactones and polylactides. XXV. Synthesis and characterization of bioerodible amphiphilic networks and their use as controlled drug delivery systems
English
Barakat, Ibrahim [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Dubois, Philippe [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Grandfils, Christian mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Robert mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
15-Jul-1999
Journal of Polymer Science. Part A, Polymer Chemistry
John Wiley & Sons
37
14
2401-2411
Yes (verified by ORBi)
International
0887-624X
Hoboken
[en] ring-opening polymerization (ROP) ; lactone ; network
[en] Well-defined ,-methacryloyl poly--caprolactone (PCL) and poly(d,l)-lactide P(D,L)LA dimacromonomers have been synthesized by living ring-opening polymerization of the parent monomers initiated by diethylaluminum 2-hydroxyethylmethacrylate (Et2AlO(CH2)2OC(O)C(CH3)CH2) and terminated by reaction of the propagating Al alkoxide groups with methacryloyl chloride. These dimacromonomers have been copolymerized with a hydrophilic comonomer, i.e., 2-hydroxyethylmethacrylate, in bulk at 65°C by using benzoyl peroxide as a free-radical initiator. The swelling ability of the amphiphilic PHEMA/PCL or P(D,L)LA networks has been investigated in both aqueous and organic media. Effect of network composition and molecular weight of the dimacromonomer on the swelling kinetics and the equilibrium solvent uptake has been studied. Lipophilic dexamethasone acetate and the hydrophilic sodium phosphate counterpart have been incorporated into the amphiphilic gels and their release has been studied in relation to the gel characteristics.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers
http://hdl.handle.net/2268/14844
10.1002/(SICI)1099-0518(19990715)37:14<2401::AID-POLA14>3.0.CO;2-9
http://www3.interscience.wiley.com/cgi-bin/fulltext/62003232/PDFSTART

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