ORBi: Lambermont Bernard - Effect of hemodiafiltration on pulmonary hemodynamics in endotoxic shock

Reference : Effect of hemodiafiltration on pulmonary hemodynamics in endotoxic shock


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Surgery Human health sciences : Laboratory medicine & medical technology
	To cite this reference:	http://hdl.handle.net/2268/14828

Title :	Effect of hemodiafiltration on pulmonary hemodynamics in endotoxic shock
Language :	English
Author, co-author :	Lambermont, Bernard [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
	Kolh, Philippe [Université de Liège - ULg > Département des Sciences biomédicales et précliniques > Service de Biochimie et de Physiologie générales, humaines, normales et pathologiques > >]
	Ghuysen, Alexandre [Université de Liège - ULg > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière]
	Moonen, M. [ > > ]
	Morimont, Philippe [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
	Gérard, Paul [Université de Liège - ULg > Département de mathématique > Statistique (aspects expérimentaux) >]
	Tchana-Sato, Vincent [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
	Rorive, Georges [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
	D'Orio, Vincenzo [Université de Liège - ULg > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path.]
Publication date :	Dec-2003
Journal title :	Artificial Organs
Publisher :	Blackwell Publishing Inc
Volume :	27
Issue/season :	12
Pages :	1128-1133
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0160-564X
City :	Malden
Keywords :	[en] endotoxins ; hemodiafiltration ; hemodynamics ; pulmonary circulation ; swine
Abstract :	[en] Hemofiltration can improve pulmonary hemodynamics during septic shock. The main objective of the study was to determine whether hemodiafiltration (HDF) would also have beneficial effects on pulmonary hemodynamics during septic shock. In the Endo group, six anesthetized pigs received a 0.5 mg/kg endotoxin infusion over 30 min. In the HDF group (n = 6), HDF was started 30 min after the end of the endotoxin infusion, while in the Control group (n = 4) they received HDF but no endotoxin infusion. Pulmonary hemodynamics were analyzed in detail with a four-element windkessel model. Although in the Control group, HDF did not alter pulmonary hemodynamic parameters, in the HDF group, it was responsible for an amplification of the deleterious pulmonary vascular response to endotoxin insult. Our results show that HDF must be used cautiously in septic shock since it can precipitate right heart failure by increasing pulmonary vascular resistance.
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/14828
Commentary :	The definitive version is available at www.blackwell-synergy.com

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