Reference : Effect of hemodiafiltration on pulmonary hemodynamics in endotoxic shock
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
Human health sciences : Surgery
http://hdl.handle.net/2268/14828
Effect of hemodiafiltration on pulmonary hemodynamics in endotoxic shock
English
Lambermont, Bernard mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Kolh, Philippe mailto [Université de Liège - ULg > Département des Sciences biomédicales et précliniques > Service de Biochimie et de Physiologie générales, humaines, normales et pathologiques > >]
Ghuysen, Alexandre mailto [Université de Liège - ULg > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière]
Moonen, M. [ > > ]
Morimont, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Gérard, Paul mailto [Université de Liège - ULg > Département de mathématique > Statistique (aspects expérimentaux) >]
Tchana-Sato, Vincent [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
Rorive, Georges mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
D'Orio, Vincenzo mailto [Université de Liège - ULg > Département des sciences cliniques > Médecine d'urgence - bioch. et phys. hum. normales et path.]
Dec-2003
Artificial Organs
Blackwell Publishing Inc
27
12
1128-1133
Yes (verified by ORBi)
International
0160-564X
Malden
[en] endotoxins ; hemodiafiltration ; hemodynamics ; pulmonary circulation ; swine
[en] Hemofiltration can improve pulmonary hemodynamics during septic shock. The main objective of the study was to determine whether hemodiafiltration (HDF) would also have beneficial effects on pulmonary hemodynamics during septic shock. In the Endo group, six anesthetized pigs received a 0.5 mg/kg endotoxin infusion over 30 min. In the HDF group (n = 6), HDF was started 30 min after the end of the endotoxin infusion, while in the Control group (n = 4) they received HDF but no endotoxin infusion. Pulmonary hemodynamics were analyzed in detail with a four-element windkessel model. Although in the Control group, HDF did not alter pulmonary hemodynamic parameters, in the HDF group, it was responsible for an amplification of the deleterious pulmonary vascular response to endotoxin insult. Our results show that HDF must be used cautiously in septic shock since it can precipitate right heart failure by increasing pulmonary vascular resistance.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/14828
The definitive version is available at www.blackwell-synergy.com

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