Article (Scientific journals)
Interactions of iturinic antibiotics with plasma membrane. Contribution of biomimetic membranes.
Nasir, Mehmet Nail; Besson, Françoise; Deleu, Magali
2013In Biotechnologie, Agronomie, Société et Environnement, 17 (3), p. 505-516
Peer Reviewed verified by ORBi
 

Files


Full Text
BASE_Nasir.pdf
Publisher postprint (947.09 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Iturin; Mycosubtilin; Bacillomycin; Liposomes; Langmuir monolayers; Lipid rafts
Abstract :
[en] Iturinic antibiotics are produced by Bacillus subtilis strains and constitute a family including iturin A, mycosubtilin and bacillomycins D, F and Lc. They are cyclic lipopeptides having -amino fatty acids linked up to a peptide constituted by seven -aminoacids with an invariable LDDLLDL chiral sequence. The first three -aminoacids containing the tyrosyl residue are the same for all members. They are well-known by their strong antifungal activities but they have also antibacterial and hemolytic properties. These biological properties are due to their amphiphilic nature allowing interactions with different membrane components. Sterols found in plasma membranes are the privileged interaction partners of these lipopeptides. Moreover, the tyrosyl residue of the iturinic antibiotics seems to play an important role during their fixation to the plasma membrane, the result of which is often the cellular lysis. Within plasma membranes, there are particular regions with high sterol content. These microdomains have a different composition compared to the rest of the membrane; they are enriched in certain lipids and proteins and they are involved in many key cellular processes. Their perturbation could then have an important impact on the cell. Due to their composition, these microdomains could constitute the preferential target of iturin antibiotics. This review aims to synthetize the works related to the biological activities of iturinic antibiotics and focusses especially to their understanding at the molecular level with a discussion on the key chemical groups of the iturin antibiotics and on the potentiality of microdomains to constitute a target for these molecules
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Nasir, Mehmet Nail ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Besson, Françoise
Deleu, Magali  ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Language :
French
Title :
Interactions of iturinic antibiotics with plasma membrane. Contribution of biomimetic membranes.
Alternative titles :
[en] Interactions des antibiotiques ituriniques avec la membrane plasmique. Apport des systèmes biomimétiques des membranes.
Publication date :
2013
Journal title :
Biotechnologie, Agronomie, Société et Environnement
ISSN :
1370-6233
eISSN :
1780-4507
Publisher :
Presses Agronomiques de Gembloux, Gembloux, Belgium
Volume :
17
Issue :
3
Pages :
505-516
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 April 2013

Statistics


Number of views
67 (14 by ULiège)
Number of downloads
7 (6 by ULiège)

Scopus citations®
 
2
Scopus citations®
without self-citations
1

Bibliography


Similar publications



Contact ORBi