Reference : Specificity of Inhibitory Deficits in Normal Aging and Alzheimer's Disease
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/14695
Specificity of Inhibitory Deficits in Normal Aging and Alzheimer's Disease
English
Collette, Fabienne mailto [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie >]
Schmidt, Christina [Université de Liège - ULg > Département des sciences cognitives > Neuropsychologie >]
Scherrer, Christine [> > > >]
Adam, Stéphane mailto [Université de Liège - ULg > Département des sciences cognitives > Département des sciences cognitives > > >]
Salmon, Eric mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
26-Apr-2009
Neurobiology of Aging
Elsevier
30
875-889
Yes (verified by ORBi)
International
0197-4580
1558-1497
New York
NY
[en] Alzheimer ; inhibition
[en] Deficits of suppression abilities are frequently observed in normal aging and Alzheimer's disease. However, few studies have explored these deficits in the two populations simultaneously using a large battery of tasks. The aim of the present study was to explore if the pattern of performance presented by elderly subjects and AD patients is in agreement with theoretical frameworks [Wilson, S.P., Harnishfeger, K.K., 1998. The development of efficient inhibition: Evidence from directed forgetting tasks. Dev. Rev. 18, 86-123; see also Nigg J.T., 2000. On inhibition/disinhibition in developmental psychopathology: views from cognitive and personality psychology and a working inhibition taxonomy. Psychol. Bull. 126, 220-246], distinguishing between the concepts of inhibition (a voluntary suppression of irrelevant information) and interference (an automatic suppression process occurring prior to conscious awareness). The results obtained demonstrated that (1) there is an alteration of the inhibitory process in normal elderly subjects; (2) inhibitory and interference resolution processes are quantitately less efficient in AD, since these patients present a correct performance only for information which leaves weak traces in memory.
Centre de Recherches du Cyclotron - CRC ; Centre de Neurosciences Cognitives et Comportementales
FRS-FNRS
Researchers ; Professionals
http://hdl.handle.net/2268/14695
10.1016/j.neurobiolaging.2007.09.007
http://www.neurobiologyofaging.org/

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