Article (Scientific journals)
Inhibitory Effects of Proanthocyanidins from Ribes Nigrum Leaves on Carrageenin Acute Inflammatory Reactions Induced in Rats
Garbacki, Nancy; Tits, Monique; Angenot, Luc et al.
2004In BMC Pharmacology, 4 (1), p. 1-9
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Abstract :
[en] BACKGROUND: The anti-inflammatory effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, were analysed using carrageenin-induced paw oedema and carrageenin-induced pleurisy in rats. RESULTS: Pretreatment of the animals with PACs (10, 30, 60 and 100 mg/kg, i.p.) reduced paw oedema induced by carrageenin in a dose and time-dependent manner. PACs also inhibited dose-dependently carrageenin-induced pleurisy in rats. They reduced (A) lung injury, (B) pleural exudate formation, (C) polymorphonuclear cell infiltration, (D) pleural exudate levels of TNF-alpha, IL-1beta and CINC-1 but did not affect IL-6 and IL-10 levels. They reduced (E) pleural exudate levels of nitrite/nitrate (NOx). In indomethacin treated rats, the volume of pleural exudate was low, its content in leukocytes and its contents in TNF-alpha, IL-1beta, IL-6 and IL-10 but not in NOx were reduced. These data suggest that the anti-inflammatory properties of PACs are achieved through a different pattern from those of indomethacin. CONCLUSION: These results suggest that the main mechanism of the anti-inflammatory effect of PACs mainly lies in an interference with the migration of the leukocytes. Moreover, PACs inhibited in vivo nitric oxide release.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Garbacki, Nancy  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Protéines et glycoprot. de matr.extracell. et membran.basal.
Tits, Monique ;  Université de Liège - ULiège > Département de pharmacie > Phytochimie et phytothérapie
Angenot, Luc  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Damas, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Language :
English
Title :
Inhibitory Effects of Proanthocyanidins from Ribes Nigrum Leaves on Carrageenin Acute Inflammatory Reactions Induced in Rats
Publication date :
21 October 2004
Journal title :
BMC Pharmacology
eISSN :
1471-2210
Publisher :
BioMed Central, United Kingdom
Volume :
4
Issue :
1
Pages :
1-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 June 2009

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