Article (Scientific journals)
Use of PIXE to measure serum copper, zinc, selenium, and bromine in patients with hematologic malignancies
Beguin, Yves; Bours, Vincent; Delbrouck, J.-M. et al.
1990In Nuclear Instruments and Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms, B49, p. 202-204
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Abstract :
[en] The use of PIXE allowed for a simultaneous determination of serum copper (Cu), zinc (Zn), selenium (Se) and bromine (Br), in various groups of patients with hematologic malignancies. In 78 patients with acute nonlymphocytic leukemia, it was observed that (1) serum Se was significantly lower than in healthy controls and correlated inversely with the tumor burden; (2) serum bromine was normal at diagnosis but dropped dramatically after intensive chemotherapy, before recovering progressively over a period of months; and (3) pretreatment serum copper and zinc were significant prognotic factors of the chance to achieve a complete remission. In 50 patients with chronic lymphocytic leukemia, it was observed that (1) serum Cu and Cu/Zn ratio were useful indices of the disease activity, which were independent of a nonspecific acute phase reaction; and (2) Zn deficiency could contribute to immune dysfunction. In 119 patients with myeloproliferative disorders or myelodysplasic syndromes, serum Cu and Zn levels were mostly dependent on nonspecific factors, such as age and inflammation.
Disciplines :
Hematology
Author, co-author :
Beguin, Yves  ;  Université de Liège - ULiège > Département des sciences cliniques > Hématologie - Oncologie médicale
Bours, Vincent ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique générale et humaine
Delbrouck, J.-M.
Robaye, G.
Roelandts, I.
Fillet, Georges ;  Université de Liège - ULiège > Département des sciences cliniques > Hématologie - Oncologie médicale
Weber, G.
Language :
English
Title :
Use of PIXE to measure serum copper, zinc, selenium, and bromine in patients with hematologic malignancies
Publication date :
1990
Journal title :
Nuclear Instruments and Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms
ISSN :
0168-583X
eISSN :
1872-9584
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
B49
Pages :
202-204
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 June 2009

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