Reference : Low frequency rythms in human DNA sequences: A key to the organization of gene location ...

	Document type :	Scientific journals : Article
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Mathematics
	To cite this reference:	http://hdl.handle.net/2268/1467

Title :	Low frequency rythms in human DNA sequences: A key to the organization of gene location and orientation?
Language :	English
Author, co-author :	Nicolay, Samuel [Université de Liège - ULg > Département de mathématique > Analyse - Analyse fonctionnelle - Ondelettes >]
	Argoul, F. [> >]
	Touchon, M. [> >]
	d'Aubenton-Carafa, Y. [> >]
	Thermes, C. [> >]
	Arneodo, A. [> >]
Publication date :	2004
Journal title :	Physical Review Letters
Publisher :	American Physical Society
Volume :	93
Issue/season :	10
Pages :	108101
Audience :	International
ISSN :	0031-9007
e-ISSN :	1079-7114
City :	Ridge
Country :	NY
Keywords :	[en] GC skew, dynamical system
Abstract :	[en] We explore large-scale nucleotide compositional fluctuations of the human genome using multi- resolution techniques. Analysis of the GC content and of the AT and GC skews reveals the existence of rhythms with two main periods of 110 20 kb and 400 50 kb that enlighten a remarkable cooperative gene organization. We show that the observed nonlinear oscillations are likely to display all the characteristic features of chaotic strange attractors which suggests a very attractive deterministic picture: gene orientation and location, in relation with the structure and dynamics of chromatin, might be governed by a low-dimensional nonlinear dynamical system.
Permalink :	http://hdl.handle.net/2268/1467
DOI :	10.1103/PhysRevLett.93.108101

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