Matrix metalloproteinases at cancer tumor-host interface

[en] The increasing diversity in both substrates and functions of matrix metalloproteinases (MMPs) makes these enzymes central regulators in the complex tumor ecosystem composed of cancer cells and their microenvironment. In the majority of cancers, membrane-associated and extracellular proteases are mainly produced by host cells including inflammatory cells, endothelial cells, pericytes and fibroblasts. Recent data based on in vitro and in vivo studies have demonstrated the relevance of these enzymes in multiple processes controlling cancer growth, angiogenesis and metastatic dissemination. This review will present the emerging MMP-related features of cancer cells and host cells.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Noël, Agnès ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme

Jost, M.

Maquoi, Erik ; Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

Language :

English

Title :

Matrix metalloproteinases at cancer tumor-host interface

Publication date :

2008

Journal title :

Seminars in Cell and Developmental Biology

ISSN :

1084-9521

eISSN :

1096-3634

Publisher :

Academic Press, London, United Kingdom

Volume :

Pages :

52-60

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 June 2009

Statistics

Number of views

162 (16 by ULiège)

Number of downloads

465 (3 by ULiège)

More statistics

Scopus citations^®

207

Scopus citations^®
without self-citations

185

OpenCitations

169

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