Reference : Matrix metalloproteinases at cancer tumor-host interface

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/14661

Title :	Matrix metalloproteinases at cancer tumor-host interface
Language :	English
Author, co-author :	Noël, Agnès [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
	Jost, M. [ > > ]
	Maquoi, Erik [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Publication date :	2008
Journal title :	Seminars in Cell & Developmental Biology
Publisher :	Academic Press
Volume :	19
Pages :	52-60
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	1084-9521
City :	London
Country :	United Kingdom
Keywords :	[en] Stromal proteases ; cancer invasion ; angiogenesis ; inflammation
Abstract :	[en] The increasing diversity in both substrates and functions of matrix metalloproteinases (MMPs) makes these enzymes central regulators in the complex tumor ecosystem composed of cancer cells and their microenvironment. In the majority of cancers, membrane-associated and extracellular proteases are mainly produced by host cells including inflammatory cells, endothelial cells, pericytes and fibroblasts. Recent data based on in vitro and in vivo studies have demonstrated the relevance of these enzymes in multiple processes controlling cancer growth, angiogenesis and metastatic dissemination. This review will present the emerging MMP-related features of cancer cells and host cells.
Permalink :	http://hdl.handle.net/2268/14661

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