Article (Scientific journals)
A feedback control perspective on models of apoptosis signal transduction
Readman, Mark C.; Schliemann, Monica; Kalamatianos, Dimitrios et al.
2013In Chaos, Solitons and Fractals
Peer Reviewed verified by ORBi
 

Files


Full Text
Readman_2013_Chaos.pdf
Publisher postprint (507.6 kB)
Request a copy
Annexes
Readman_2013_Chaos=Supplemental_Material.pdf
(319.46 kB)
Supplementary Material
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Apoptosis is a key regulator for replacing unused, old and damaged cells. Here we analyse three models of apoptosis. We deconstruct these models by linearising the models about the life steady state and applying methods from linear control theory. This control viewpoint uncovers a decentralised control scheme with a clear separation of plant and controller and reveals that the caspase inhibitors act as decentralised phase lead controllers. © 2013 Elsevier Ltd. All rights reserved.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Readman, Mark C.;  School of Mathematics, The University of Manchester, Manchester, England, United Kingdom
Schliemann, Monica;  Department of Electrical Engineering and Computer Science (Institut Montefiore) and GIGA (Interdisciplinary Cluster for Applied Geno-proteomics), Université de Liège, Belgium
Kalamatianos, Dimitrios;  Division of Developmental Biology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
Bullinger, Eric ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation : Méth. computat. pour la bio.syst.
Language :
English
Title :
A feedback control perspective on models of apoptosis signal transduction
Publication date :
2013
Journal title :
Chaos, Solitons and Fractals
ISSN :
0960-0779
Publisher :
Pergamon Press - An Imprint of Elsevier Science
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
National Biophotonics and Imaging Platform, Ireland
Fondation Francqui [BE]
Belgian Network DYSCO (Dynamical Systems, Control, and Optimisation)
Available on ORBi :
since 09 April 2013

Statistics


Number of views
67 (7 by ULiège)
Number of downloads
1 (1 by ULiège)

Scopus citations®
 
1
Scopus citations®
without self-citations
0
OpenCitations
 
1

Bibliography


Similar publications



Contact ORBi