Article (Scientific journals)
Evaluation of the residual solvent content of counterfeit tablets and capsules
Deconinck, Eric; Canfyn, Michael; Sacre, Pierre-Yves et al.
2013In Journal of Pharmaceutical and Biomedical Analysis, 81-82, p. 80-88
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Keywords :
counterfeit Medicines; Gas Chromatography; Residual Solvents
Abstract :
[en] A group of counterfeit samples of Viagra® and Cialis® were screened for their residual solvent content and compared to the content of the genuine products. It was observed that all counterfeit samples had higher residual solvent contents compared to the genuine products. A more diverse range of residual solvents was found as well as higher concentrations. In general these concentrations did not exceed the international imposed maximum limits. Only in a few samples the limits were exceeded. A Projection Pursuit analysis revealed clusters of samples with similar residual solvent content, possibly enabling some future perspectives in forensic research.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Deconinck, Eric
Canfyn, Michael
Sacre, Pierre-Yves  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Courselle, Patricia
De Beer, Jacques
Language :
English
Title :
Evaluation of the residual solvent content of counterfeit tablets and capsules
Publication date :
July 2013
Journal title :
Journal of Pharmaceutical and Biomedical Analysis
ISSN :
0731-7085
eISSN :
1873-264X
Publisher :
Elsevier Science, Oxford, United Kingdom
Volume :
81-82
Pages :
80-88
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 April 2013

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