Article (Scientific journals)
Association between Epstein-Barr virus and Hodgkin's lymphoma in Belgium: A pathological and virological study
Trimeche, M.; Bonnet, Christophe; Korbi, S. et al.
2007In Leukemia and Lymphoma, 48 (7), p. 1323-1331
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Keywords :
Epstein-Barr virus; Hodgkin's lymphoma; latent membrane protein-1 deletions; typing of EBV; polymerase chain reaction; in situ hybridization
Abstract :
[en] The association between Epstein-Barr virus (EBV) and classical Hodgkin's lymphoma (cHL) varies according to the geographic location. In this work we sought to characterize EBV involvement in a series of 111 cHL cases diagnosed in Belgium. The overall prevalence of EBV infection detected by in situ hybridization in Reed-Sternberg cells was 33%. EBV positivity correlated with older age at diagnosis (454 years; p = 0.01), mixed cellularity subtype (p = 0.000001), male gender (p = 0.004) and tended to be associated with higher clinical stage (III/IV; p = 0.02). The molecular features of the virus in EBV-positive cHL were studied by comparison with a series of reactive tonsils. A 30-bp deletion within the LMP-1 gene was in 15/28 (53.6%) EBV-positive cHL cases, and in 41.7% of reactive tonsil samples. This variant did not correlate with any clinical or pathological feature. The EBV strain was type A in all cHL and reactive samples.
Disciplines :
Hematology
Author, co-author :
Trimeche, M.
Bonnet, Christophe ;  Université de Liège - ULiège > GIGA-R : Hématologie
Korbi, S.
Boniver, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
de Leval, Laurence ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Language :
English
Title :
Association between Epstein-Barr virus and Hodgkin's lymphoma in Belgium: A pathological and virological study
Publication date :
2007
Journal title :
Leukemia and Lymphoma
ISSN :
1042-8194
eISSN :
1029-2403
Publisher :
Taylor & Francis Ltd, Abingdon, United Kingdom
Volume :
48
Issue :
7
Pages :
1323-1331
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 05 April 2013

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