Levels of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls in human milk from different regions of France
[en] Wereport on the pilot study carried out before the start of the Elfe project (French longitudinal study from childhood). A total of 44 samples of mature human milk were collected at home 8 weeks after delivery. A total of 7 polychlorinated dibenzo-p-dioxins (PCDDs), 10 polychlorinated dibenzofurans (PCDFs), 12 dioxin-like (DL) polychlorinated biphenyls (PCBs), and 6 non dioxin-like (NDL)-PCBs were measured. For total TEQ (PCDD/Fs and DL-PCBs), the geometric mean concentration was 17.81 pg TEQWHO05/g lipids. Relative PCDD, PCDF, and DL-PCB contributions to the arithmetic mean TEQWHO05 were 38%, 18%, and 44%, respectively. The use of TEFWHO05 instead of TEFWHO98 resulted in a 27% reduction of the total TEQ value. Although PCDD levels did not significantly change (less than 0.5% increase), PCDF and DL-PCB levels both decreased by 35% and 38%, respectively. Levels have been compared to data obtained during a previous non-reported national study conducted in 1998 (TEFWHO98) in French lactaria (n = 244). The mean of PCDD/Fs has decreased about 39.4% (18.8 pg TEQWHO98/g lipids in 1998 vs 11.4 pg TEQWHO98/g lipids in pilot study), respectively 41.5% for PCDDs (10.6 pg TEQWHO98/g lipids in 1998 vs 6.2 pg TEQWHO98/g lipids in pilot study) and 36.7% for PCDFs (7.9 pg TEQWHO98/g lipids in 1998 vs 5.0 pg TEQWHO98/g lipids in pilot study). For the sum of the 6 NDL-PCBs, the 2007 geometric mean concentration in milk was 176.3 ng/g lipids. The arithmetic mean lipid concentration in 2007 breast milk was 26.4 g/l (range from 6.0 to 46.7 g/l). A PCDD/F and DL-PCB daily intake was estimated to be 62.3 pg
TEQWHO05/kg body weight per day (85.0 pg TEQWHO98/kg bodyweight per day) for a baby of 5 kg of bodyweight fed daily with 700 ml of maternal milk containing 25 g/l of lipids.
Disciplines :
Chemistry
Author, co-author :
Focant, Jean-François ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique, organique et biologique
Fréry, N
Bidondo, ML
Eppe, Gauthier ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique
Scholl, Georges ; Université de Liège - ULiège > Center for Analytical Research and Technology (CART)
Saoudi, A
Oleko, A
Vandentorren, S
Language :
English
Title :
Levels of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls in human milk from different regions of France
Abballe A., Ballard T.J., Dellatte E., Domenico A., Ferri F., Fulgenzi A.R., et al. Persistent environmental contaminants in human milk: concentrations and time trends in Italy. Chemosphere 2008, 73:S220-S227.
Bake M.A., Linnika Z., Sudmalis P., Kočan A., Jursa S., Pike A., et al. Assessment of the exposure of breast milk to persistent organic pollutants in Latvia. Int J Hyg Environ Health 2007, 210(3-4):483-489.
Bencko V., Cerna M., Jech L., Smid J. Exposure of breast-fed children in the Czech Republic to PCDDs, PCDFs, and dioxin-like PCBs. ICCM-2004 Symposium 2004, 18:83-90.
Cerná M., Krsková A., Cejchanová M., Spevácková V. Human biomonitoring in the Czech Republic: an overview. Int J Hyg Environ Health 2012, 215(2):109-119.
Citepa, Centre interprofessionnel technique d'études de la pollution atmosphérique Ministère de l'écologie, du développement durable, des transports et du logement. Inventaire des émissions des polluants atmosphériques et des gaz à effet de serre en France - Séries sectorielles et analyse étendue 2011, Ed. Citépa, Paris, France, [325 pp.].
Cok I., Donmez M.K., Uner M., Demirkaya E., Henkelmann B., Shen H., et al. Polychlorinated dibenzo-p-dioxins, dibenzofurans and polychlorinated biphenyls levels in human breast milk from different regions of Turkey. Chemosphere 2009, 76:1563-1571.
Commission Regulation (EC) No 1259/2011 Commission Regulation (EC) No 1259/2011 of 2 December 2011 amending Regulation (EC) No 1881/2006 as regards maximum levels for dioxins, dioxin-like PCBs and non dioxin-like PCBs in foodstuffs. Off J Eur Union 2011, L320:18-23.
Commission Regulation 252/2012 Commission Regulation 252/2012, 2012 of 21 March 2012 laying down methods of sampling and analysis for the official control of levels of dioxins, dioxin-like PCBs and non-dioxin-like PCBs in certain foodstuffs and repealing Regulation (EC) No 1883/2006. Off J Eur Union 2012, L84:1-22.
Costopoulou D., Vassiliadou I., Papadopoulos A., Makropoulos V., Leondiadis L. Levels of dioxins, furans and PCBs in human serum and milk of people living in Greece. Chemosphere 2006, 65:1462-1469.
EPA, Environmental Protection Agency Exposure and human health reassessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds National Academy Sciences (NAS) 2007, US Environmental Protection Agency, (http://www8.nationalacademies.org/cp/projectview.aspx?key=103).
Eppe G., De Pauw E. Advances in quality control for dioxins monitoring and evaluation of measurement uncertainty from quality control data. J Chromatogr B 2009, 877:2380-2387.
Ferriby L.L., Knutsen J.S., Harris M., Unice K.M., Scott P., Nony P., et al. Evaluation of PCDD/F and dioxin-like PCB serum concentration data from the 2001-2002 National Health and Nutrition Examination Survey of the United States population. J Expo Sci Environ Epidemiol 2007, 17:358-371.
Focant J.F. Dioxin food crises and new POPs: challenges in analysis. Anal Bioanal Chem 2012, 403:2797-2800.
Focant J.F., De Pauw E. Fast automated extraction and clean-up of biological fluids for polychlorinated dibenzo-p-dioxins, dibenzofurans and coplanar polychlorinated biphenyls analysis. J Chromatogr B 2002, 776:199-212.
Focant J.F., Eppe G., Pirard C., De Pauw E. Fast clean-up for polychlorinated dibenzo-p-dioxins, dibenzofurans and coplanar polychlorinated biphenyls analysis of high-fat-content biological samples. J Chromatogr A 2001, 925:207-221.
Focant J.F., Pirard C., Thielen C., De Pauw E. Levels and profiles of PCDDs, PCDFs and cPCBs in Belgian human milk: estimation of infant intake. Chemosphere 2002, 48:763-770.
Focant J.F., Pirard C., De Pauw E. Automated sample preparation-fractionation for the measurement of dioxins and related compounds in biological matrices: a review. Talanta 2004, 63:1101-1113.
Focant J.F., Eppe G., Massart A.C., Scholl G., Pirard C., De Pauw E. High-throughput biomonitoring of dioxins and polychlorinated biphenyls at the sub-picogram level in human serum. J Chromatogr A 2006, 1130:97-107.
Fréry N., Deloraine A., Zeghnoun A., Rouvière F., Cordier S., Bard D., et al. Etude sur les dioxines et les furanes dans le lait maternel en France 2000, Institut de veille sanitaire, Saint-Maurice, (175 pp., http://opac.invs.sante.fr/index.php?lvl=notice_display&id=6063).
Fréry N., Deloraine A., Dor F., Zeghnoun A., Rouvière F. Dioxins and furans in breast milk in France. Organohalogen Compd 2000, 48:47-48.
Fréry N., Zeghnoun A., Sarter H., Volatier J.L., Falq G., Pascal M., et al. Confounding factors influencing serum dioxin concentrations in the French dioxin and incinerators study. Organohalogen Compd 2007, 69:1013-1016.
Fromme H., Albrecht M., Boehmer S., Büchner K., Mayer R., Liebl B., et al. Intake and body burden of dioxin-like compounds in Germany: the INES study. Chemosphere 2009, 76(11):1457-1463.
Hardell E., Carlberg M., Nordström M., van Bavel B. Time trends of persistent organic pollutants in Sweden during 1993-2007 and relation to age, gender, body mass index, breast-feeding and parity. Sci Total Environ 2010, 408(20):4412-4419.
Harden F.A., Toms L.M.L., et al. Evaluation of dioxin-like chemicals in pooled human milk samples collected in Australia. Chemosphere 2007, 67(9):S325-S333.
Helsel D.R. Nondetects and data analysis: statistics for censored environmental data 2005, John Wiley and Sons, New Jersey. 1st ed.
JECFA Joint FAO/WHO Expert Committee on Food Additives. Summary and conclusions 2001, [Available at http://www.who.int/pcs/jecfa/jecfa.htm].
Kishikawa N., Kuroda N. Evaluation of organic environmental pollutants detected in human milk. Review. J Health Sci 2009, 55(1):1-10.
Lakind J.S. Recent global trends and physiologic origins of dioxins and furans in human milk. J Expo Sci Environ Epidemiol 2007, 17:510-524.
LaKind J.S., Berlin C.M., Park C.N., Naiman D.Q., Gudka N.J. Methodology for characterizing distributions of incremental body burdens of 2,3,7,8-TCDD and DDE from breast milk in North American nursing infants. J Toxicol Environ Health A 2000, 59:605-639.
Lignell S., Glynn A.W., Darnerud P.O., Aune M., Bjerselius R., Baumann B., et al. Time trend of dioxins in breast milk in Sweden 1996-2004. Organohalogen Compd 2005, 67:1770-1773.
Malisch R., van Leeuwen F.X.R. Results of the WHO-coordinated study on the levels of PCBs, PCDDs and PCDFs in human milk. Organohalogen Compd 2003, 64:136-140.
Malisch R., Kotz A., Wahl K., Malisch K., Tritscher A., Lee S.Y., et al. WHO/UNEP-coordinated exposure studies on levels of PCDD/F and PCBs (dioxin-like and non dioxin-like) in human milk. Data presented at the Seventh PCB Workshop, May 27-31 2012, Arcachon, France 2012.
National Action Plan on PCBs/ Plan national d'actions sur les polychlorobiphényles (PCB) Comité national de pilotage et de suivi du mercredi 6 février 2008. Ministère de l'Écologie, du Développement et de l'Aménagement durables, Ministère de l'Agriculture et de la Pêche, Ministère de la Santé, de la Jeunesse et des Sports 2008, [http://www.developpement-durable.gouv.fr/IMG/spipwwwmedad/pdf/Plan_actions_PCB_Details_cle578f3f.pdf].
Norén K., Meironyté D. Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30years. Chemosphere 2000, 40(9-11):1111-1123.
Pirard C., De Pauw E., Focant J.F. New strategy for comprehensive analysis of polybrominated diphenyl ethers, polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls by gas chromatography coupled with mass spectrometry. J Chromatogr A 2003, 998:169-181.
Polder A., Savinova T.N., Becher G., Skaare J.U. Temporal changes of PCBs, PCDD/PCDFs and chlorinated pesticides in human milk from Murmansk, Russia, and Tromsø, Norway. Organohalogen Compd 2004, 66:2761-2765.
Potera C. Exposure now, sickness later. Environ Health Perspect 2000, 108:A574.
Raab U., Schwegler U., Preiss U., Albrecht M., Fromme H. Bavarian breast milk survey - pilot study and future developments. Int J Hyg Environ Health 2007, 210:341-344.
Reis F., Sampaio C., Aguiar P., Melim M., Miguel J.P., Päpke O. Biomonitoring of PCDD/Fs in populations living near Portuguese solid waste incinerators: levels in human milk. Chemosphere 2007, 67:S231-S237.
Salanave B., de Launay C., Guerrisi C., Castetbon K. Breastfeeding rates in maternity units and at 1month. Results from the Epifane survey, France, 2012. Bull Epidemiol hebd 2012, 34:383-387.
Schuhmacher M., Domingo J.L., Kiviranta H., Vartiainen T. Monitoring dioxins and furans in a population living near a hazardous waste incinerator: levels in breast milk. Chemosphere 2004, 57(1):43-49.
Scientific Committee on Food Opinion of the SCF on the risk assessment of dioxins and dioxin-like PCBs in food. Report CS/CNTM/DIOXIN/20 Final 2001.
Sim M.R., McNeil J.J. Monitoring chemical exposure using breast milk: a methodological review. Am J Epidemiol 1992, 136(1):1-11.
Sirot V., Tard A., Venisseau A., Brosseaud A., Marchand P., Le Bizec B., et al. Dietary exposure to polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls of the French population: results of the second French Total Diet Study. Chemosphere 2012, 88:492-500.
Stockholm Convention Text at. http://www.pops.int.
Sun S.J., Zhao J.H., Liu H.J., Liu D.W., Ma Y.X., Li L., et al. Dioxin concentration in human milk in Hebei province in China and Tokyo, Japan: potential dietary risk factors and determination of possible sources. Chemosphere 2006, 62:1879-1888.
Takekuma M., Saito K., Falandysz J., Nakazawa H. Ratio variation of congener profiles of PCDD/Fs and dioxin-like PCBs in human milk during lactation. Sci Total Environ 2011, 409:1368-1377.
Tard A., Gallotti S., Leblanc J.C., Volatier J.L. Dioxins, furans and dioxin-like PCBs: occurrence in food and dietary intake in France. Food Addit Contam 2007, 24(9):1007-1017.
Ulaszewska M.M., Zuccato E., Davoli E. PCDD/Fs and dioxin-like PCBs in human milk and estimation of infants' daily intake: a review. Chemosphere 2011, 83:774-782.
Van den Berg M., Birnbaum L., Bosveld A.T., Brunstrom B., Cook P., Feeley M., et al. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Health Perspect 1998, 106(12):775-792.
Van den Berg M., Birnbaum L.S., Denison M., De Vito M., Farland W., Feeley M., et al. The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 2006, 93(2):223-241.
Vandentorren S., Bois C., Pirus C., Sarter H., Salines G., Leridon H., et al. Rationales, design and recruitment for the Elfe longitudinal study. BMC Pediatr 2009, 9:58-68.
Wang R.Y., Jain R.B., Wolkin A.F., Rubin C.H., Needham L.L. Serum concentrations of selected persistent organic pollutants in a sample of pregnant females and changes in their concentrations during gestation. Environ Health Perspect 2009, 117(8):1244-1249.
WHO The optimal duration of exclusive breastfeeding. Report of an expert consultation 2001, WHO.
WHO, World Health Organization Fourth WHO-coordinated survey of human milk for persistent organic pollutants in cooperation with UNEP. Guidelines for developing a national protocol 2007, (Revised 1 October 2007. http://www.who.int/foodsafety/chem/POPprotocol.pdf).
WHO, World Health Organization.ENHIS, European Environment and Health Information System Persistent organic pollutants in human milk. Fact Sheet 4.3, December 2009, Code: RPG4 Food Ex2 2009.
Wittsiepe J., Fürst P., Schrey P., Lemm F., Kraft M., Eberwein G., et al. PCDD/F and dioxin-like PCB in human blood and milk from German mothers. Chemosphere 2007, 67(9):S286-S294.