Reference : pH-responsive flower-type micelles formed by a biotinylated poly(2-vinylpyridine)-blo...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Engineering, computing & technology : Materials science & engineering
http://hdl.handle.net/2268/14589
pH-responsive flower-type micelles formed by a biotinylated poly(2-vinylpyridine)-block-poly(ethylene-oxide)-block-poly(ε-caprolactone) triblock copolymer
English
Van Butsele, Kathy [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Cajot, Sébastien [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Van Vlierberghe, Sandra [University of Gent > > Polymer Chemistry & Biomaterials Research Group > >]
Dubruel, Peter [University of Gent > > Polymer Chemistry & Biomaterials Research Group > >]
Passirani, Catherine [University of Angers, France > > INSERM U 646 > >]
Benoit, Jean-Pierre [University of Angers, France > > INSERM U 646 > >]
Jérôme, Robert mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Jérôme, Christine mailto [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
8-May-2009
Advanced Functional Materials
Wiley
19
9
1416-1425
Yes (verified by ORBi)
International
1616-301X
[en] self-assembly in solution ; micelle ; stimuli-responsive polymer ; pH-sensitive polymer ; block copolymer ; stimuli responsive micelle
[en] In the present work, a method is proposed to assemble pH-responsive, flower-like micelles that can expose a targeting unit at their periphery upon a decrease in pH. The micelles are composed of a novel biotinylated triblock copolymer of poly(-caprolactone)-block-poly(ethylene oxide)-block-poly(2-vinylpyridine) (PCL-b-PEO-b-P2VP) and the non-biotinylated analogue. The block copolymers are synthesized by sequential anionic and ring-opening polymerization. The pH-dependent micellization behaviour in aqueous solution of the triblock copolymers developed is studied using dynamic light scattering, zeta potential, transmission electron microscopy (TEM), and fluorimetric measurements. The shielding of the biotin at neutral pH and their availability at the micelle surface upon protonation is established by TEM and surface plasmon resonance with avidin and streptavidin-coated gold surfaces. The preliminary stealthy behavior of these pH-responsive micelles is examined using the complement activation (CH50) test.
Center for Education and Research on Macromolecules (CERM)
Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; The "Région Wallonne" in the frame of the "VACCINOR" program (WINNOMAT) ; The CGRI-FNRS-Inserm cooperation program
Researchers
http://hdl.handle.net/2268/14589
10.1002/adfm.200801117
http://www3.interscience.wiley.com/cgi-bin/fulltext/122267111/PDFSTART

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