pH-responsive flower-type micelles formed by a biotinylated poly(2-vinylpyridine)-block-poly(ethylene-oxide)-block-poly(ε-caprolactone) triblock copolymer

Van Butsele, Kathy; Cajot, Sébastien; Van Vlierberghe, Sandra; Dubruel, Peter; Passirani, Catherine; Benoit, Jean-Pierre; Jérôme, Robert; Jérôme, Christine

doi:10.1002/adfm.200801117

Article (Scientific journals)

pH-responsive flower-type micelles formed by a biotinylated poly(2-vinylpyridine)-block-poly(ethylene-oxide)-block-poly(ε-caprolactone) triblock copolymer

Van Butsele, Kathy; Cajot, Sébastien; Van Vlierberghe, Sandra et al.

2009 • In Advanced Functional Materials, 19 (9), p. 1416-1425

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/14589

DOI
10.1002/adfm.200801117

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Keywords :

self-assembly in solution; micelle; stimuli-responsive polymer; pH-sensitive polymer; block copolymer; stimuli responsive micelle

Abstract :

[en] In the present work, a method is proposed to assemble pH-responsive, flower-like micelles that can expose a targeting unit at their periphery upon a decrease in pH. The micelles are composed of a novel biotinylated triblock copolymer of poly(-caprolactone)-block-poly(ethylene oxide)-block-poly(2-vinylpyridine) (PCL-b-PEO-b-P2VP) and the non-biotinylated analogue. The block copolymers are synthesized by sequential anionic and ring-opening polymerization. The pH-dependent micellization behaviour in aqueous solution of the triblock copolymers developed is studied using dynamic light scattering, zeta potential, transmission electron microscopy (TEM), and fluorimetric measurements. The shielding of the biotin at neutral pH and their availability at the micelle surface upon protonation is established by TEM and surface plasmon resonance with avidin and streptavidin-coated gold surfaces. The preliminary stealthy behavior of these pH-responsive micelles is examined using the complement activation (CH50) test.

Research center :

Center for Education and Research on Macromolecules (CERM)

Disciplines :

Materials science & engineering
Chemistry

Author, co-author :

Van Butsele, Kathy ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Cajot, Sébastien ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Van Vlierberghe, Sandra; University of Gent > Polymer Chemistry & Biomaterials Research Group

Dubruel, Peter; University of Gent > Polymer Chemistry & Biomaterials Research Group

Passirani, Catherine; University of Angers, France > INSERM U 646

Benoit, Jean-Pierre; University of Angers, France > INSERM U 646

Jérôme, Robert ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Jérôme, Christine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Language :

English

Title :

pH-responsive flower-type micelles formed by a biotinylated poly(2-vinylpyridine)-block-poly(ethylene-oxide)-block-poly(ε-caprolactone) triblock copolymer

Publication date :

08 May 2009

Journal title :

Advanced Functional Materials

ISSN :

1616-301X

eISSN :

1616-3028

Publisher :

Wiley

Volume :

Issue :

Pages :

1416-1425

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www3.interscience.wiley.com/cgi-bin/fulltext/122267111/PDFSTART

Name of the research project :

"VACCINOR" program (WINNOMAT); The CGRI-FNRS-Inserm cooperation program

Funders :

BELSPO - Politique scientifique fédérale [BE]
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
Région wallonne [BE]

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