ORBi: Escarabajal Dolores M. - Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats

Reference : Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Psychiatry Human health sciences : Pharmacy, pharmacology & toxicology Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/1458

Title :	Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats
Language :	English
Author, co-author :	Escarabajal, Dolores M. [Universidad de Jaén > Area de Psicobiologia > > >]
	De Witte, Philippe [Université Catholique de Louvain - UCL > > Biologie du Comportement > >]
	Quertemont, Etienne [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
Publication date :	2003
Journal title :	Psychopharmacology
Publisher :	Springer Verlag
Volume :	167
Issue/season :	2
Pages :	130-136
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0033-3158
City :	Berlin
Country :	Germany
Keywords :	[en] ethanol ; acetaldehyde ; conditioned taste aversion ; cyanamide ; aldehyde dehydrogenase
Abstract :	[en] Rationale: In spite of many recent studies on the effects of acetaldehyde, it is still unclear whether acetaldehyde mediates the reinforcing and/or aversive effects of ethanol. Objectives: The present study reexamined the role of acetaldehyde in ethanol-induced conditioned taste aversion (CTA). A first experiment compared ethanol- and acetaldehyde-induced CTA. In a second experiment, cyanamide, an aldehyde dehydrogenase inhibitor, was administered before conditioning with either ethanol or acetaldehyde to investigate the effects of acetaldehyde accumulation. Methods: A classic CTA protocol was used to associate the taste of a saccharin solution with either ethanol or acetaldehyde injections. In experiment 1, saccharin consumption was followed by injections of either ethanol (0, 0.5, 1.0, 1.5 or 2.0 g/kg) or acetaldehyde (0, 100, 170 or 300 mg/kg). In experiment 2, the rats were pretreated with either saline or cyanamide (25 mg/kg) before conditioning with either ethanol or acetaldehyde. Results: Both ethanol and acetaldehyde induced significant CTA. However, ethanol produced a very strong CTA relative to acetaldehyde that induced only a weak CTA even at toxic doses. Cyanamide pretreatments significantly potentiated ethanol- but not acetaldehyde-induced CTA. Conclusions: The present results indicate that ethanol-induced CTA does not result from brain acetaldehyde effects. In contrast, it is suggested that the reinforcing effects of brain acetaldehyde might actually reduce ethanol-induced CTA. Our results also suggest that the inhibition of brain catalase activity may contribute to the potentiating effects of cyanamide on ethanol-induced CTA.
Research units :	Centre de Neurosciences Cognitives et Comportementales
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/1458
DOI :	10.1007/s00213-003-1427-9

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