ORBi: Williams S. A. - Time-course of brain ethanol levels and the acoustic startle response in the rat following the acute administration of ethanol

Reference : Time-course of brain ethanol levels and the acoustic startle response in the rat followi...


	Document type :	Scientific congresses and symposiums : Paper published in a journal
	Discipline(s) :	Social & behavioral sciences, psychology : Neurosciences & behavior
	To cite this reference:	http://hdl.handle.net/2268/14574

Title :	Time-course of brain ethanol levels and the acoustic startle response in the rat following the acute administration of ethanol
Language :	English
Author, co-author :	Williams, S. A. [Wake Forest Univesity > > > >]
	Quertemont, Etienne [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
	Green, Heather [Wake Forest Univesity > > > >]
	Grant, Kathleen A. [Wake Forest Univesity > > > >]
	Lyons, Dave [Wake Forest Univesity > > > >]
Publication date :	2001
Journal title :	Alcoholism, Clinical & Experimental Research
Publisher :	Blackwell Publishing
Volume :	25
Pages :	110A-110A
Audience :	International
ISSN :	0145-6008
e-ISSN :	1530-0277
City :	Oxford
Country :	United Kingdom
Event name :	24th Annual Research Society on Alcoholism Scientific Meeting
Event date :	du 22 au 28 juin 2001
Event organizer :	Research Society on Alcoholism (RSA)
Event place (city) :	Montréal
Event country :	Canada
Keywords :	[en] Ethanol ; Startle response ; Microdialysis
Abstract :	[en] It is known that ethanol administration inhibits the acoustic startle response, but whether this sensitivity varies within-session has not been investigated. The purpose of the present study was to compare the time-course of ethanol levels in brain with alterations in the acoustic startle response. Three experiments were conducted in adult male Sprague-Dawley rats. 1) Ethanol concentrations in brain were determined by microdialysis following the acute administration of 0.3, 1.0 and 3.0 g/kg ig of ethanol. 2) The effect of ethanol on the acoustic startle response was determined after the same doses. 3) The acoustic startle response was determined during two time periods, at 2-18 and 30-46 minutes, after ethanol administration to evaluate periods of ascending and descending ethanol levels. In expt. 1, brain levels of ethanol rose rapidly, peaking within 4-8 minutes following all doses. In expt. 2, ethanol administration reduced the acoustic startle response in a dose-related manner; all doses significantly reduced the response. In expt. 3, prepulse inhibition was diminished by ethanol during a very short period immediately after ethanol administration, whereas the acoustic startle response was inhibited only during later times. These data indicate that the acoustic startle response was exquisitely sensitive to ethanol, even at doses as low as 0.3 g/kg. In addition, prepulse inhibition was selectively disrupted immediately after ethanol administration, which suggests that this phenomenon may accompany the short-lived ascending limb of the brain ethanol curve. Supported by AA 12356 (DL) and AA11997.
Research units :	Centre de Neurosciences Cognitives et Comportementales
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/14574

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