Calcium Phosphate; Biomaterials; Bone regeneration
Abstract :
[en] Aim: Sub-sinusal bone regeneration procedures are reliable procedures that are known to be efficient with the use of biomaterials alone. Nevertheless, many types of biomaterials are available, and their efficacy in terms of bone formation and resorption rate have rarely been compared. This study aimed to compare the bone formation, resorption rate, osteoconductivity and 3D volume changes of three biomaterials often used for alveolar ridge augmentation.
Materials and Methods: Rabbits underwent a double sinus lift procedure using three different types of space fillers: bovine hydroxyapatite (BHA), beta calcium phosphate (ß-TCP) and biphasic calcium phosphate (BCP). Animals were sacrificed at 1 week, 5 weeks and 6 months. Samples were subjected to X-ray microtomography and histology. Qualitative analysis was performed on non-decalcified sections, and quantitative histomorphometric analysis was conducted using SEM. Volume variations of bone augmentations were calculated at different time points.
Results: All three particulated biomaterials proved to be effective in promoting osteogenesis. At 6 months, biomaterial resorption rates were significantly different across the 3 groups (p<0.0001). The highest resorption rate was found with β-TCP, in which only 6.7% of the baseline particle surface remained. At 6 months, bone was in close contact with the BHA particles, constituting a composite network; in contrast, BCP particles were often surrounded by soft tissues. In each group, no significant difference in volume variations were found at the different time point.
Conclusions and clinical implications: Despite the limitations of the study, the three particulated space-filling biomaterials proved to be efficient to promote osteogenesis. High resorption rates and complete replacement of the biomaterials by bone seemed to withstand intrasinusal pressure. Further investigations in humans should consider longer follow-up periods.
Disciplines :
Dentistry & oral medicine
Author, co-author :
LAMBERT, France ; Centre Hospitalier Universitaire de Liège - CHU > Médecine dentaire
Léonard, Angélique ; Université de Liège - ULiège > Département de chimie appliquée > Génie chimique - Procédés et développement durable
LECLOUX, Geoffrey ; Centre Hospitalier Universitaire de Liège - CHU > Médecine dentaire
Sourice, Sophie; University of Nantes, Nantes, France > Laboratory for osteo-articular and dental tissue engineering > INSERM U 791
Pilet, Paul; CHU Nantes, Nantes, France / University of Nantes, Nantes, France > INSERM U 791, Laboratory for osteo-articular and dental tissue engineering, > Service d’Odontologie conservatrice Endodontie
ROMPEN, Eric ; Centre Hospitalier Universitaire de Liège - CHU > Médecine dentaire
Language :
English
Title :
A comparison of three calcium phosphate based space fillers in sinus elevation: a study in rabbits
Publication date :
2013
Journal title :
International Journal of Oral and Maxillofacial Implants
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