Article (Scientific journals)
Kinetics of IL-7 and IL-15 Levels after Allogeneic Peripheral Blood Stem Cell Transplantation following Nonmyeloablative Conditioning
De Bock, Muriel; Fillet, Marianne; Hannon, Muriel et al.
2013In PLoS ONE, 8 (2), p. 55876
Peer Reviewed verified by ORBi
 

Files


Full Text
Baron-IL-7 and IL-15 after allo-HSCT-Plos One 2013.pdf
Publisher postprint (496.27 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Background: We analysed kinetics of IL-7 and IL-15 levels in 70 patients given peripheral blood stem cells after nonmyeloablative conditioning. Methods: EDTA-anticoagulated plasma and serum samples were obtained before conditioning and about once per week after transplantation until day 100. Samples were aliquoted and stored at 280uC within 3 hours after collection until measurement of cytokines. IL-7 and IL-15 levels were measured by ELISAs. Results: Median IL-7 plasma levels remained below 6 pg/L throughout the first 100 days, although IL-7 plasma levels were significantly higher on days 7 (5.1 pg/mL, P = 0.002), 14 (5.2 pg/mL, P,0.001), and 28 (5.1 pg/mL, P = 0.03) (but not thereafter) than before transplantation (median value of 3.8 pg/mL). Median IL-15 serum levels were significantly higher on days 7 (12.5 pg/mL, P,0.001), 14 (10.5 pg/mL, P,0.001), and 28 (6.2 pg/mL, P,0.001) than before transplantation (median value of 2.4 pg/mL). Importantly, IL-7 and IL-15 levels on days 7 or 14 after transplantation did not predict grade II–IV acute GVHD. Conclusions: These data suggest that IL-7 and IL-15 levels remain relatively low after nonmyeloablative transplantation, and that IL-7 and IL-15 levels early after nonmyeloablative transplantation do not predict for acute GVHD.
Disciplines :
Hematology
Author, co-author :
De Bock, Muriel
Fillet, Marianne ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Hannon, Muriel ;  Université de Liège - ULiège > GIGA-R : Hématologie
Seidel, Laurence  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
Merville, Marie-Paule ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Gothot, André ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Beguin, Yves  ;  Université de Liège - ULiège > GIGA-R : Hématologie
Baron, Frédéric  ;  Université de Liège - ULiège > GIGA-R : Hématologie
Language :
English
Title :
Kinetics of IL-7 and IL-15 Levels after Allogeneic Peripheral Blood Stem Cell Transplantation following Nonmyeloablative Conditioning
Publication date :
2013
Journal title :
PLoS ONE
eISSN :
1932-6203
Publisher :
Public Library of Science, San Franscisco, United States - California
Volume :
8
Issue :
2
Pages :
e55876
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 March 2013

Statistics


Number of views
43 (8 by ULiège)
Number of downloads
150 (3 by ULiège)

Scopus citations®
 
9
Scopus citations®
without self-citations
6
OpenCitations
 
9

Bibliography


Similar publications



Contact ORBi