Article (Scientific journals)
Lactase Insufficiency Revisited
Forget, P; Lombet, Jacques; Grandfils, Christian et al.
1985In Journal of Pediatric Gastroenterology and Nutrition, 4, p. 868-872
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Keywords :
Lactase; Small bowel; Lactose breath hydrogen test
Abstract :
[en] The definition of "insufficient" small bowel lactase activity varies greatly among authors. The present study is aimed at redefining lactase insufficiency by comparing intestinal lactase activity and results of the lactose breath hydrogen test. Primary "insufficient" lactase activity was considered to be present when a child with a normal small bowel histology showed lactose malabsorption as measured by the lactose breath hydrogen test. The lactase activity of 22 "normal" children ranged from 0.77 to 4.57 U/g wet weight, while five children showed primary lactase insufficiency as defined above. Small bowel lactase activity in the latter patients was < 0.74 U/g wet weight. Sucrase and maltase activities were similar in both groups of patients. We conclude that children with a normal small bowel histology should be considered to have primary lactase insufficiency when small bowel lactase activity is below 0.75 U/g wet weight.
Research center :
Department of Pediatrics and Department of General and Comparative Biochemistry
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Forget, P
Lombet, Jacques;  Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > NÉPHROLOGIE PÉDIATRIQUE
Grandfils, Christian ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Dandrifosse, Guy ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Geubelle, Fernand
Language :
English
Title :
Lactase Insufficiency Revisited
Publication date :
1985
Journal title :
Journal of Pediatric Gastroenterology and Nutrition
ISSN :
0277-2116
eISSN :
1536-4801
Publisher :
Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania
Volume :
4
Pages :
868-872
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 March 2013

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