Microencapsulation; Coacervation; Surface tension; Interfacial; Tension; Polylactide; Polylactide-co-glycolide; Protein encapsulation
Abstract :
[en] This paper is related to the phase separation of different copolyesters of lactides and glycolide solutions induced by the addition of silicone oil in order to promote microencapsulation of proteins. This coating process can be divided in three successive steps: phase separation of the coating polymer; adsorption of the coacervate droplets around the drugs phase, and microcapsule solidification. This paper focuses on the physico-chemical analysis of the second step. The knowledge of the interfacial tensions between the three liquid phases allows understanding of the microscopic evolution of the phase separation medium.
Research center :
Center for Education and Research on Macromolecules (CERM) - University of Liege
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Nihant, Nicole
Stassen, S
Grandfils, Christian ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Jérôme, Robert ; Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences)
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