[en] This paper describes the phase separation of different lactide and glycolide copolyester solutions, induced by the addition of silicone oil in order to promote protein microencapsulation. The phase diagrams of the ternary CH2Cl2-copolyester-silicone oil systems were established in relation to the composition of the copolyester and the viscosity, i.e. the molecular weight, of the silicone oil. The phase-separated systems were characterized in terms of weight, volume, composition and viscosity of the coacervation agent (silicone oil) on the characteristics of the phase-separated system is discussed.
Research center :
Center for Education and Research on Macromolecules (CERM) - University of Liege
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Stassen, S; Université de Liège - ULiège > Center for Education and Research on Macromolecules (CERM)
Nihant, Nicole; Université de Liège - ULiège > Center for Education and Research on Macromolecules (CERM)
Martin, Véronique
Grandfils, Christian ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Jérôme, Robert ; Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences)
Teyssié, Philippe ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Microencapsulation by coacervation of poly(lactide-co-glycolide): Physico-chemical characteristics of the phase separation process
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