Reference : Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/14458
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
English
Lahortiga, Idoya [> > > >]
De Keersmaecker, Kim [> > > >]
Van Vlierberghe, Pieter [> > > >]
Graux, C. [> > > >]
Cauwelier, B. [> > > >]
Lambert, Frédéric mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
Mentens, N. [> > > >]
Beverloo, H. B. [> > > >]
Pieters, R. [> > > >]
Speleman, F. [> > > >]
Odero, M. D. [> > > >]
Bauters, M. [> > > >]
Froyen, G. [> > > >]
Marynen, P. [> > > >]
Vandenberghe, P. [> > > >]
Wlodarska, I. [> > > >]
Meijerink, J. P. P. [> > > >]
Cools, J. [> > > >]
May-2007
Nature Genetics
Nature Publishing Group
39
5
593-595
Yes (verified by ORBi)
International
1061-4036
New York
[en] We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.
Researchers ; Professionals
http://hdl.handle.net/2268/14458
10.1038/ng2025

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