[en] To investigate metabolic relationships between different brain regions in schizophrenia, we measured regional brain metabolism using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG) in 15 unmedicated schizophrenic patients and 15 healthy subjects. We analyzed correlations between glucose metabolism data of multiple brain regions using factorial analysis and correlation coefficient comparisons. Absolute regional intercorrelations in schizophrenic brains were found to be significantly stronger than in controls, in relationship to the greater variability of metabolic rates in schizophrenic patients. Variability of normalized metabolic rates and regional intercorrelations were not significantly different between schizophrenic patients and control subjects. We conclude that a global metabolic factor accounts for the variability of metabolic data in untreated schizophrenia.
Disciplines :
Neurosciences & behavior
Author, co-author :
Biver, Françoise
Goldman, Serge
De Maertelaer, Viviane
Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Mendlewicz, Julien
Lotstra, Françoise
Language :
English
Title :
Interregional correlation of cerebral glucose metabolism in unmedicated schizophrenia
Andreasen, N.C., Rezai, K., Alliger, R., Swayze, V.W., Flaum, M., Kirchner, P., Cohen, G. and O'Leary, D.S. (1992) Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia. Arch. Gen. Psychiatry 49, 943-958.
Buchsbaum, M.S., Ingvar, D.H., Kessler, R., Waters, R.N., Cappelletti, J., van Kammen, D.P., King, A.C., Johnson, J.L., Manning, R.G., Flynn, R.W., Mann, L.S., Bunney, W.E. and Sokoloff, L. (1982) Cerebral glucography with positron tomography; use in normal subjects and in patients with schizophrenia. Arch. Gen. Psychiatry 39, 251-259.
Buchsbaum, M.S., De Lisi, L.E., Holcomb, H.H., Cappelletti, J., King, A.C., Johnson, J., Hazlett, E., Dowling-Zimmerman, S., Post, R.M., Morihisa, J., Carpenter, W., Cohen, R., Pickar, D., Weinberger, D.R., Margolin, R. and Kessler, R.M. (1984) Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Arch. Gen. Psychiatry 41, 1159-1166.
Buchsbaum, M.S., Nuechterlein, K.H., Haier, R.J., Wu, J., Sicotte, N., Hazlett, E., Asarnow, R., Potkin, S. and Guich, S. (1990) Glucose metabolic rate in normals and schizophrenics during the continuous performance test assessed by positron emission tomography. Br. J. Psychiatry 156, 216-227.
Clark, C.M., Kessler, R., Buchsbaum, M.S., Margolin, R.A. and Holcomb, H.H. (1984) Correlational methods for determining regional coupling of cerebral glucose metabolism: a pilot study. Biol. Psychiatry 19(5), 663-678.
Cleghorn, J.M., Garnett, E.S., Nahmias, C., Firnau, G., Brown, G.M., Kaplan, R., Szechtman, H. and Zsechtman, B. (1989) Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia. Psychiatr. Res. 28, 119-133.
De Lisi, L.E., Buchsbaum, M.S., Holcomb, H.H., Langston, K.C., King, A.C., Kessler, R., Pickar, D., Carpenter, W.J., Morihisa, J.M., Margolin, R. and Weinberger, D.R. (1989) Increased temporal lobe glucose use in chronic schizophrenic patients. Biol. Psychiatry 25, 835-851.
Friston, K.J., Liddle, P.F., Frith, C.D., Hirsch, S.R. and Frackowiak, R.S. (1992) The left medial temporal region and schizophrenia. A PET study. Brain 115, 367-382.
Grace, A.A. (1991) Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience 41, 1-24.
McCrory, S.J. and Ford, I. (1991) Multivariate analysis of SPECT images with illustrations in Alzheimer's disease. Stat. Med. 10, 1711-1718.
Metter, E.G., Riege, W.H., Kuhl, D.E. and Phelps, M.E. (1984a) Cerebral metabolic relationships for selected brain regions in healthy adults. J. Cereb. Blood Flow Metab. 4, 1-7.
Metter, E.G., Riege, W.H., Kameyama, M., Kuhl, D.E. and Phelps, M.E. (1984b) Cerebral metabolic relationships for selected brain regions in Alzheimer's, Huntington's and Parkinson's diseases. J. Cereb. Blood Flow Metab. 4, 500-506.
Phelps, M.E., Huang, S.C., Hoffman, E.J., Selin, C., Sokoloff, L. and Kuhl, D.E. (1979) Tomographic measurement of local cerebral glucose metabolic rate in humans with [18F] 2-fluoro-2-deoxy-D-glucose: validation of method. Ann. Neurol. 6, 371-388.
Roberts, G.W. (1990) Schizophrenia: the cellular biology of a functional psychosis. TINS 13, 207-211.
Sokoloff, L., Reivich, M., Kennedy, C., Des Rosiers, M.H., Patlak, C.S., Pettigrew, K.D., Sakurada, O. and Shinohara, M. (1977) The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28, 897-916.
Szechtman, H., Nahmias, C., Garnett, E.S., Firnau, G., Brown, G.M., Kaplan, R.D. and Cleghorn, J.M. (1988) Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia. Arch. Gen. Psychiatry 45, 523-532.
Talairach, J. and Tournoux, P. (1988) Co-planar Stereotaxic Atlas of the Human Brain 3-Dimensional Proportional System: An Approach to Cerebral Imaging. Georg Thieme Verlag/Thieme Medical Publishers Inc., New York.
Tamminga, C.A., Thaker, G.K., Buchanan, R., Kirkpatrick, B., Alphs, L.D., Chase, T.N. and Carpenter, W.T. (1992) Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Arch. Gen. Psychiatry 49, 522-530.
Volkow, N.D., Brodie, J.D., Wolf, A.P., Gomez, M.F., Cancro, R., Van Guelder, G.P., Russell, J.A. and Overall, J. (1986) Brain organization in schizophrenia. J. Cereb. Blood Flow Metab. 6, 441-446.
Volkow, N.D., Wolf, A.P., Van Guelder, P., Brodie, J.D., Overall, J.E., Cancro, R. and Gomez, M.F. (1987) Phenomenological correlates of metabolic activity in 18 patients with chronic schizophrenia. Am. J. Psychiatry 144(2), 151-158.
Weinberger, D.R. (1988) Schizophrenia and the frontal lobe. TINS 11, 367-370.
Williamson, P. (1987) Hypofrontality in schizophrenia: a review of the evidence. Can. J. Psychiatry 32, 399-404.
