Article (Scientific journals)
Deciphering supportive treatment strategies for toxic epidermal necrolysis.
Jennes, Serge; PIERARD, Gérald; Paquet, Philippe
2012In Current Drug Safety, 7 (5), p. 361-6
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Abstract :
[en] Toxic epidermal necrolysis (TEN) is a dreadful life-threatening syndrome typically induced by an adverse drug reaction. This condition is characterized by the sudden and extensive destruction of the epidermis. The patient should be promptly addressed to a burn unit where three types of treatment should be administered, namely, (a) specific topical care of the bullous/eroded skin areas, (b) systemic anti-apoptotic/necrotic treatments, and (c) supportive care preventing secondary internal organ failures. This latter aspect is covered by the present review and focuses on (a) early withdrawal of the causative drug, (b) airway management, (c) hydro-electrolytic control, (d) nutritional support, (e) antibiotherapy, (f) prevention of venous thrombosis and gastroduodenal ulcers, and (g) analgesia and anesthesia.
Disciplines :
Dermatology
Author, co-author :
Jennes, Serge;  Military Hospital Bruxelles > Burn Unit
PIERARD, Gérald ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Paquet, Philippe
Language :
English
Title :
Deciphering supportive treatment strategies for toxic epidermal necrolysis.
Publication date :
2012
Journal title :
Current Drug Safety
ISSN :
1574-8863
eISSN :
2212-3911
Publisher :
Bentham Science Publishers, United Arab Emirates
Volume :
7
Issue :
5
Pages :
361-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 March 2013

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