Article (Scientific journals)
Ipilimumab induces simultaneous regression of melanocytic naevi and melanoma metastases
LIBON, Florence; ARRESE ESTRADA, Jorge; RORIVET, A. et al.
2012In Clinical and Experimental Dermatology, (4452), p. 1-4
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Keywords :
Ipilimumab; melanocytic naevi; melanoma metastases
Abstract :
[en] Background : Ipilimumab blocks cytotoxic T-lymphocyte-associated antigen (CTLA)-4, potentiating the antimelanoma T-cell host reponse. Ipilimumab has been shown to improve overall survival in patients with previously treated metastatic melanoma. CTLA-4 antibodies generate immune responses to the melanoma-associated antigens Melan-A, NY-ESO-1 and glycoprotein (gp) 100 in metastatic melanoma. Digital epiluminescence microscopy (DELM) is a noninvasive method permitting the monitoring of the morphology of melanocytic lesions over time. Observation : A 50-year-old man with metastatic melanoma received four ipilimumab injections after failure of dacarbazine chemotherapy. Positron emission tomography revealed regression of pulmonary metastases, and simultaneously, DELM showed regression of several melanocytic naevi. On histological examination of the regressing naevi, prominent CD8+, CD4+ and CD45R0 lichenoid lymphohistiocytic infiltrates were seen, whereas nonregressing naevi were almost free of inflammatory infiltrate. Conclusion : Expression of melanoma-associated antigens in benign melanocytic naevi may explain the induction of naevus regression by ipilimumab. DELM could represent a valuable noninvasive method to monitor ipilimumab efficacy.
Disciplines :
Dermatology
Author, co-author :
LIBON, Florence ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
ARRESE ESTRADA, Jorge ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
RORIVET, A.
NIKKELS, Arjen ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatologie
Language :
English
Title :
Ipilimumab induces simultaneous regression of melanocytic naevi and melanoma metastases
Alternative titles :
[fr] L'Ipilimubab induit une régression simultanée de naevus mélanocytaire et métastases de mélanome
Publication date :
23 July 2012
Journal title :
Clinical and Experimental Dermatology
ISSN :
0307-6938
eISSN :
1365-2230
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Issue :
4452
Pages :
1-4
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 February 2013

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