Article (Scientific journals)
Les maladies complexes: l'importance de la genetique.
LIBIOULLE, Cécile; BOURS, Vincent
2012In Revue Médicale de Liège, 67 (5-6), p. 220-5
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Keywords :
Base Sequence; Causality; Disease/etiology/genetics; Gene-Environment Interaction; Genetic Diseases, Inborn/epidemiology/etiology; Genetic Predisposition to Disease/etiology/genetics; Humans; Inheritance Patterns/genetics/physiology; Molecular Sequence Data; Mutation; Twins
Abstract :
[en] Complex diseases usually harbour hereditary factors linked with multiple susceptibility genes. The additive effects of genetic and environmental factors are responsible for the pathology. The impact of heredity has been demonstrated through family studies, but also, and mostly, through the study of adopted people and twins. Recently, genome wide association studies (GWAS) allowed the identification of many susceptibility genes for most complex diseases. However, a large part of the heritability is still missing, probably because of insufficient exploration of rare genetic variants and/or epigenetic factors. The ultimate goal of these genetic studies is the definition of an individual risk leading to specific preventive measures (model "predict and prevent"), but this purpose remains very remote for the majority of complex diseases.
Disciplines :
Genetics & genetic processes
Author, co-author :
LIBIOULLE, Cécile  
BOURS, Vincent ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
Language :
French
Title :
Les maladies complexes: l'importance de la genetique.
Alternative titles :
[en] Complex diseases: the importance of genetics
Publication date :
2012
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
67
Issue :
5-6
Pages :
220-5
Peer reviewed :
Peer reviewed
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since 10 February 2013

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